以氩气代替价格昂贵的氦气作为实时直接分析质谱(DART-MS)的工作气体以降低实验成本. 甲醇和乙醇作为作为两种辅助性反应试剂,在Ar-DART-MS分析中充当能量传递的媒介和质子的供体,可以提高Ar-DART-MS的电离效率并扩展其应用范围. 通过甲醇和乙醇作为反应性试剂在Ar-DART-MS的背景信号及对样品电离影响的分析,探讨了它们的应用范围,以及在电离过程中存在的一些可能的特征反应. 该方法的有效性通过对利血平的分析结果获得.
In this research, argon was used as the running gas in direct analysis in real time mass spectrometry instead of helium in order to reduce the cost of experiment.Methanol and alcohol as reactive reagents improve the ionization efficiency of analytes and expand the application of Ar-DART-MS.This is because the above reagents play important roles as the medium of the energy transferring and the domor of proton in Ar-DART-MS analysis.Through the analysis of background signal from methol and alcohol as reactive reagents in Ar-DART-MS and their affect on sample ionization, the application scope of methanol and alcohol as reactive reagents in Ar-DART-MS was discussed.Some possible characteristic reactions were also explored.The validity of this method was verified by the analysis of reserpine.
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