The titanium enrichment (66%, mole fraction) alloy was melted in the BaZrO3 crucible to investigate the crucible damage and erosion mechanism. By the optical microscopy, scanning electron microscopy, X-ray diffractometry and atomic emission spectrometry, the microstructure and the dissolution of BaZrO3 refractory after contacting the melt with different time were studied. The results show that the thickness of erosion layer of the BaZrO3 crucible is measured as about 2000 μm. The Zr and O elements contents in the alloys increase with rising the contacting time. The damage of BaZrO3 crucible is caused by the changing of crystal volume, as the BaO transforms into BaCO3. The main mechanism responsible for the erosion of BaZrO3 crucible is the dissolution of BaZrO3 refractory in the titanium enrichment melt.