In order to investigate the dynamic response of horizontal goaf group in complicated combination under residual mining excitation, a dynamic response modal of horizontal goaf group in complicated combination was established based on structural discrete. Dynamic response and stress transfer of horizontal goaf group in complicated combination on Level 1100 m of KT8 ore body in a large underground gold mine were researched combined with numerical simulation. The results indicate that the structure change of horizontal goaf group can not influence the displacement and velocity response of rock mass that blasting excites, while it would obviously increase the response of residual rock mass, among which the area of maximum increment belongs to structure change sector. Blasting load obviously impacts on stress distribution of rock mass it effects on while others not. Field engineering results show that goaf newly formed is in stable state and has no large displacement and deformation in the surrounding area after residual mining of horizontal goaf group in complicated combination, which verifies the reliability of dynamic response modal. A theoretical guidance has been provided for residual mining of horizontal goaf group in complicated combination.