采用硅烷偶联剂(KH550)和L-丙交酯LLA联合接枝处理的新方法对纳米羟基磷灰石(n-HA)进行表面改性,然后将其与聚乳酸-羟基乙酸(PLGA)作不同比例复合(n-HA为3wt％、10wt％、20wt％及30wt％),得到改性n-HA/PLGA复合材料(g-n-HA/PLGA).将其与未改性n-HA及未改性n-HA/PLGA复合材料作对比检测.结果表明,该联合处理方法是n-HA进行表面接枝改性的新型有效方法.且改性处理后的n-HA与未改性处理的n-HA相比,能更好地在PLGA基体中分散均匀,并能提高PLGA结晶能力和PLGA的力学性能.当改性处理后的n-HA添加量为10wt％时,其复合材料抗弯强度和拉伸强度分别比未改性n-HA/PLGA提高14.4％和11.3％.该新型g-n-HA/PLGA复合材料有望用作骨折固定材料.
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