The ibuprofen-rectorite composites were prepared by the solution intercalation method using ibuprofen and rectorite as raw materials,and were characterized by X-ray diffraction (XRD)analysis,Fourier transform infrared analysis and scanning electron microscopy(SEM).The experimental results show that the ibuprofen is intercalated into the interlayer spaces of rectorite.The values of the(001)peaks of the ibuprofen-rectorite composite are larger than that of Na-rectorite and reach the largest when the reaction time and ibuprofen amount is 2 h and 0.36 g,respectively.The layered structure of Na-rectorite is destroyed to some extent with the intercalation of ibuprofen into the interlayer space in the structure of Na-rectorite.A part of ibuprofen in the ibuprofen Na-rectorite covers on the surface of Na-rectorite besides some ibuprofen enters into the interlayer space.
参考文献
[1] | M. Melillo;G. J. Phillips;J. G. Davies .The effect of protein binding on ibuprofen adsorption to activated carbons[J].Carbon: An International Journal Sponsored by the American Carbon Society,2004(3):565-571. |
[2] | Uhrich Kathryn E.;Cannizzaro,Scott M. .Polymeric Systems for Controlled Drug Release[J].Chemical Reviews,1999(11):3181-3198. |
[3] | Lee WF.;Fu YT. .Effect of montmorillonite on the swelling behavior and drug-release behavior of nanocomposite hydrogels[J].Journal of Applied Polymer Science,2003(13):3652-3660. |
[4] | Choy JH;Jung JS;Oh JM;Park M;Jeong J;Kang YK;Han OJ .Layered double hydroxide as an efficient drug reservoir for folate derivatives.[J].Biomaterials,2004(15):3059-3064. |
[5] | Hyun Jung;Hyun-Mi Kim;Young Bin Choy;Seong-Ju Hwang;Jin-Ho Choy .Itraconazole-Laponite: Kinetics and mechanism of drug release[J].Applied clay science,2008(1/4):99-107. |
[6] | Jung H;Kim HM;Choy YB;Hwang SJ;Choy JH .Laponite-based nanohybrid for enhanced solubility and controlled release of itraconazole.[J].International Journal of Pharmaceutics,2008(1/2):283-290. |
[7] | Lin FH;Lee YH;Jian CH;Wong JM;Shieh MJ;Wang CY .A study of purified montmorillonite intercalated with 5-fluorouracil as drug carrier.[J].Biomaterials,2002(9):1981-1987. |
[8] | Dong YC;Feng SS .Poly(D,L-lactide-co-glycolide)/montmorillonite nanoparticles for oral delivery of anticancer drugs[J].Biomaterials,2005(30):6068-6076. |
[9] | J.P. Zheng;L. Luan;H.Y. Wang;L.F. Xi;K.D. Yao .Study on ibuprofen/montmorillonite intercalation composites as drug release system[J].Applied clay science,2007(4):297-301. |
[10] | Xiaoying Wang;Yumin Du;Jiwen Luo .Chitosan/organic rectorite nanocomposite films:Structure,characteristic and drug delivery behaviour[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2007(1):41-49. |
[11] | 王慧燕.布洛芬-累托石复合物的制备及特征[J].武汉理工大学学报,2008(08):8-10,22. |
[12] | Li ZH;Jiang WT;Hong HL .An FTIR investigation of hexadecyltrimethylammonium intercalation into rectorite[J].Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy,2008(4):1525-1534. |
[13] | Hanlie Hong;Wei-Teh Jiang;Xiaoling Zhang;Liyun Tie;Zhaohui Li .Adsorption Of Cr(vi) On Stac-modified Rectorite[J].Applied clay science,2008(1/2):292-299. |
[14] | Xu D;Chen CL;Tan XL;Hu J;Wang XK .Sorption of Th(IV) on Na-rectorite: Effect of HA, ionic strength, foreign ions and temperature[J].Applied Geochemistry: Journal of the International Association of Geochemistry and Cosmochemistry,2007(12):2892-2906. |
[15] | 王倩,杨星昊,刘海,乔玉芬.布洛芬/HP-β-CD包合物固态体系的表征和溶解性能研究[J].中国新药杂志,2006(11):878-883. |
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