Chitosan-g-PAA Hydrogels for Colon-Specific Drug Delivery: Preparation, Swelling Behavior and in vitro Degradability

武汉理工大学学报-材料科学版(英文版), 2010, 25(2): 248-251. doi: 10.1007/s11595-010-2248-4

^1, , ^2, , ^3, , ^4, , ^5,

1.School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

2.Department of Pharmaceutical Engineering, School of Chemistry Engineering, Wuhan University of Technology, Wuhan 430070, China

3.Department of Pharmaceutical Engineering, School of Chemistry Engineering, Wuhan University of Technology, Wuhan 430070, China

4.Department of Pharmaceutical Engineering, School of Chemistry Engineering, Wuhan University of Technology, Wuhan 430070, China

5.Department of Pharmaceutical Engineering, School of Chemistry Engineering, Wuhan University of Technology, Wuhan 430070, China

基金项目: the National Natural Science Foundation of China(50503019)

Chitosan-g-PAA Hydrogels for Colon-Specific Drug Delivery: Preparation, Swelling Behavior and in vitro Degradability

GONG Shiqiong ^1, , TU Houwei ^2, , ZHENG Hua ^3, , XU Haixing ^4, , YIN Yihua ^5,

1.School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

2.Department of Pharmaceutical Engineering, School of Chemistry Engineering, Wuhan University of Technology, Wuhan 430070, China

3.Department of Pharmaceutical Engineering, School of Chemistry Engineering, Wuhan University of Technology, Wuhan 430070, China

4.Department of Pharmaceutical Engineering, School of Chemistry Engineering, Wuhan University of Technology, Wuhan 430070, China

5.Department of Pharmaceutical Engineering, School of Chemistry Engineering, Wuhan University of Technology, Wuhan 430070, China

Keywords： hydrogel

A series of cross-linked hydrogels for colon-specific drug delivery were synthesized by graft copolymerization of Chitosan and acrylic acid using N, N' -methylene-bis-(acrylamide) as a cross-linker. Their swelling behavior in different pH buffer solutions and colonic enzymatic degradability were studied. The obtained results show that these hydrogels have good pH sensitivity which can avoid drug release in stomach, and their swelling kinetics in stimulant intestinal environment follow second-order swelling kinetics equation. The factors influencing the swelling kinetics include the degree of cross-linking and the composition, which may control no release or a little amount release of drug inside the hydrogels in the small intestine by tailoring these factors. The gels are degradable by colonic enzymes and there is a correlativity between the degradation of networks and the swelling degree of the gels, which may trigger the release of drug in the colon. The hydrogels show a great potential for their application in oral colon-specific drug delivery system.

参考文献

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Chitosan-g-PAA Hydrogels for Colon-Specific Drug Delivery: Preparation, Swelling Behavior and in vitro Degradability

参考文献