纯水中有氧条件下Pd/C催化的无配体Suzuki反应

催化学报 , 2014, (3): 357-361. doi: 10.1016/S1872-2067(12)60754-2

纯水中有氧条件下Pd/C催化的无配体Suzuki反应

饶小峰 ^1, , 刘春 ^2, , 张义霞 ^3, , 高占明 ^4, , 金子林 ^5,

1.大连理工大学精细化工国家重点实验室，辽宁大连116024

2.大连理工大学精细化工国家重点实验室，辽宁大连116024

3.大连理工大学精细化工国家重点实验室，辽宁大连116024

4.大连理工大学精细化工国家重点实验室，辽宁大连116024

5.大连理工大学精细化工国家重点实验室，辽宁大连116024

基金项目: the National Natural Science Foundation of China(21276043) the Ministry of Education Program for New Century Excellent Talents in University (NCET-10-0283)@@@@国家自然科学基金(21276043) 教育部新世纪优秀人才支持计划(NCET-10-0283)

关键词： Suzuki反应 , 钯 , 碳 , 无配体 , 二异丙胺 , 联芳化合物

Pd/C-catalyzed ligand-free and aerobic Suzuki reaction in water

Xiaofeng Rao ^1, , Chun Liu ^2, , Yixia Zhang ^3, , Zhanming Gao ^4, , Zilin Jin ^5,

1.大连理工大学精细化工国家重点实验室，辽宁大连116024

2.大连理工大学精细化工国家重点实验室，辽宁大连116024

3.大连理工大学精细化工国家重点实验室，辽宁大连116024

4.大连理工大学精细化工国家重点实验室，辽宁大连116024

5.大连理工大学精细化工国家重点实验室，辽宁大连116024

Keywords： Suzuki reaction , Palladium , Carbon , Ligand-free , Diisopropylamine , Biaryl

报道一种在纯水中Pd/C催化的高效Suzuki反应体系，该体系无需除氧，且无外加配体和添加剂，底物普适性广泛，含有亲水或疏水基团的溴代芳烃都能被高效活化。此外，对部分杂环芳烃与芳基硼酸的偶联反应也有较好的催化效果。该催化剂可高效循环使用三次，且性能无明显下降。

A general and efficient catalytic system for Pd/C-catalyzed ligand-free aerobic Suzuki cross-coupling reactions was developed. The reaction tolerated a wide range of aryl bromides with a hydrophilic group or a hydrophobic group without any additives in water. Moreover, the catalytic system was successfully extended to the cross-couplings of heteroaryl halides with various arylboronic acids. The Pd/C catalyst could be reused three times without significant loss of catalytic activity.

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