Synthesis of Ag nanoparticles for the electrochemical detection of anticancer drug flutamide

催化学报 , 2015, (3): 439-445. doi: 10.1016/S1872-2067(14)60209-6

Farzaneh Ahmadi ^1, , Jahan Bakhsh Raoof ^2, , Reza Ojani ^3, , Mehdi Baghayeri ^4, , Moslem Mansour Lakouraj ^5, , Hamed Tashakkorian ^6,

1.Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

2.Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

3.Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

4.Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

5.Department of 0rganic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

6.Department of 0rganic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

Synthesis of Ag nanoparticles for the electrochemical detection of anticancer drug flutamide

Keywords： Silver nanoparticle

Ag nanoparticles were synthesized on the surface of a glassy carbon electrode modified with p‐tert‐butylcalix[4]arene and p‐tert‐butylcalix[6]arene by the deposition of Ag+at an open circuit potential followed by the electrochemical reduction of the Ag+. The presence of the calixarene layer on the electrode surface controlled the particle size and prevented agglomeration. Cyclic voltam‐metry showed that the Ag nanoparticles on the modified glassy carbon electrode had good catalytic ability for the reduction of flutamide. The effects of calixarene concentration, potential applied for the reduction of Ag+, number of calixarene layers, and pH value on the electrocatalytic activity of the Ag nanoparticles were investigated. The modified electrode had a linear range in differential pulse voltammetry of 10?1000 μmol/L with a detection limit of 9.33 μmol/L for flutamide at an S/N=3. The method was applied to the detection of flutamide in practical samples.

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Synthesis of Ag nanoparticles for the electrochemical detection of anticancer drug flutamide

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