通过Domino脱HCl/Pd(OAc)2催化的Heck反应实现了β-氯代烷基芳基酮、酯和酰胺与卤代芳烃的交叉偶联反应，高效合成了查尔酮类化合物。利用原位生成烯酮为中间体进行反应的策略，减少副反应的发生，从而提高反应的效率。该方法对各种官能团的容忍性好，为从氯代烷烃出发直接合成查尔酮类化合物提供了一条新途径。
A new method has been developed for the cross‐coupling of aryl halides with β‐chloroalkyl aryl ketones and their ester and amide analogs through a domino dehydrochlorination/Pd(OAc)2‐cata‐lyzed Heck reaction sequence. The enone intermediates generated in situ reduced the occurrence of side reactions and therefore enhanced the efficiency of the reaction. This reaction exhibited good tolerance to various functional groups on both substrates and provides rapid access to a wide range of chalcone derivatives.
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