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采用炭/炭复合材料制备了骨组织改建支架,并对所制支架进行了表面形貌观察、痕量元素分析和体内生物学性能评价.结果表明:所制支架能够有效实现对自体移植骨的支撑和骨性融合,生物相容性良好.亦即,表面多孔炭/炭复合材料能够满足作为骨组织改建支架材料的成分要求.

A carbon/carbon composite scaffold for bone tissue reconstruction was prepared. The surface morphology and trace elements of the scaffold were analyzed and its biological behavior was studied both in vitro and in vitro. It was found that the scaffold had a good biocompatibility, not only resulting from its high purity and mild cell toxicity, but also from the excellent integration of the bone tissue with the composite scaffold during the reconstruction.

参考文献

[1] Yu. S. Virgil'ev;I. P. Kalyagina .Carbon-Carbon Composite Materials[J].Inorganic materials,2004(s1):S33-S49.
[2] Howling G;Ingham E .Carbon-carbon composite bearing materials in hip arthroplasty:analysis of wear and biological[J].Journal of Materials Science:Materials in Medicine,2004,15:91-98.
[3] Li H;Zou X;Woo C;Ding M;Lind M;Bunger C .Experimental lumbar spine fusion with novel tantalum-coated carbon fiber implant.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2007(1):194-200.
[4] Cao,N.;Dong,J.;Wang,Q.;Ma,Q.;Wang,F.;Chen,H.;Xue,C.;Li,M. .Plasma-sprayed hydroxyapatite coating on carbon/carbon composite scaffolds for bone tissue engineering and related tests in vivo[J].Journal of biomedical materials research, Part A,2010(3):1019-1027.
[5] Noriyuki T;Akira M;Tetsuya T .Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo[J].Journal of Biomedical Materials Research,2002,59(01):110-117.
[6] Jordan DR;Brownstein S;Dorey M;Yuen VH;Gilberg S .Fibrovascularization of porous polyethylene (Medpor) orbital implant in a rabbit model.[J].Ophthalmic plastic and reconstructive surgery,2004(2):136-143.
[7] Ning Cao;Musen Li;Quansheng Ma .Biomedical Coatings Prepared on Carbon/Carbon Composites[J].Science and Engineering of Composite Materials,2007(3):241-249.
[8] Niinomi M. .Mechanical properties of biomedical titanium alloys[J].Materials Science & Engineering, A. Structural Materials: Properties, Misrostructure and Processing,1998(1/2):231-236.
[9] Long M;Rack HJ .Titanium alloys in total joint replacement--a materials science perspective.[J].Biomaterials,1998(18):1621-1639.
[10] Jenkins G M;Grigson C J .The fabrication of artifacts out of glassy carbon and carbon-fiber-reinforced carbon for biomedical applications[J].Journal of Biomedical Materials Research,1979,13:371-394.
[11] Larry L. Hench .Bioceramics[J].Journal of the American Ceramic Society,1998(7):1705-1728.
[12] Witte F;Feyerabend F;Maier P;Fischer J;Stormer M;Blawert C;Dietzel W;Hort N .Biodegradable magnesium-hydroxyapatite metal matrix composites.[J].Biomaterials,2007(13):2163-2174.
[13] Li S;Zheng Z;Liu Q;de-Wijn JR;de-Groot K .Collagen/apatite coating on 3-dimensional carbon/carbon composite.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(4):520-529.
[14] Cao N;Ma QS;Sui JL;Wang QX;Lu YP;Chen YM;Li MS .The experiment of plasma-sprayed HA coatings on carbon/carbon composites in bone[J].Surface review and letters,2006(4):423-428.
[15] Nazzal A;Lozano Calderon S;Jupiter JB;Rosenzweig JS;Randolph MA;Lee SG .A histologic analysis of the effects of stainless steel and titanium implants adjacent to tendons: an experimental rabbit study.[J].Journal of Hand Surgery. American Volume,2006(7):1123-1130.
[16] Lucie Bacakova;Vladimir Stary .Polishing and coating carbon fiber-reinforced carbon composites with a carbon-titanium layer enhances adhesion and growth of osteoblast-like MG63 cells and vascular smooth muscle cells in vitro[J].Journal of biomedical materials research, Part B. Applied biomaterials,2001(4):567-578.
[17] Hench L L .Bioceramics:from comcept to clinic[J].Journal of the American Ceramic Society,1991,74(07):1487-1510.
[18] W. W. LU;F. ZHAO;K. D. K. LUK;Y. J. YIN;K. M. C. CHEUNG;G. X. CHENG;K. D. YAO;J. C. Y. LEONG .Controllable porosity hydroxyapatite ceramics as spine cage: fabrication and properties evaluation[J].Journal of Materials Science. Materials in Medicine,2003(12):1039-1046.
[19] Lewandowska Szumiel-M;Komender J;Chlopek J .Interaction between carbon composites and bone after intrabone implantation.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1999(3):289-296.
[20] Pesakova V;Klezl Z;Balik K .Biomechanical and biological properties of the implant materials carbon-carbon composite covered with pyrolytic carbon[J].Journal of Materials Science:Materials in Medicine,2000,11:793-798.
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