Mediating Mesenchymal Stem Cells Responses and Osteopontin Adsorption via Oligo(ethylene glycol)-amino Mixed Self-assembled Monolayers

材料科学技术（英文）, 2016, 32(9): 966-970. doi: 10.1016/j.jmst.2016.04.005

Mediating Mesenchymal Stem Cells Responses and Osteopontin Adsorption via Oligo(ethylene glycol)-amino Mixed Self-assembled Monolayers

Hao Lijing ^1,2, , Li Tianjie ^1,2, , Zhao Naru ^1,2, , Cui Fuzhai ^3, , Du Chang ^1,2,*,, , Wang Yingjun ^1,2,*,,

1. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China

2. National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China

3. Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China

Correspondence author: Du Chang, duchang@scut.edu.cnCorrespondence author: Wang Yingjun, imWangyj@163.com

Keywords： Mixed self-assembled monolayers , Oligo(ethylene glycol)-amino , Mesenchymal stem cell , Osteopontin

Oligo(ethylene glycol) (-OEG) and amino (-NH₂) mixed self-assembled monolayers (SAMs) were employed as model substrates to investigate the effect of charge density on the fate of mesenchymal stem cells (MSCs) and osteopontin (OPN) adsorption. We found that all surfaces presenting -NH₂ groups favored cell responses regardless of the surface charge. Meanwhile, OPN adsorption could remain stable on the mixed SAMs over a certain range of charge densities. Our work provides some insights into cell responses and protein adsorption to surface charge.

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Mediating Mesenchymal Stem Cells Responses and Osteopontin Adsorption via Oligo(ethylene glycol)-amino Mixed Self-assembled Monolayers

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