以苯甲酸四乙铵为引发剂,引发β-苹果酸苄基内酯(MLABe)和β-丁内酯(BL)开环共聚,得到聚(β-苹果酸苄基酯-co-β-羟基丁酸酯)(P (MLABe-co-BL))共聚物.通过核磁共振氢谱(1H-NMR)、核磁共振碳谱(13C-NMR)和红外光谱(FTIR)表征,表明合成了聚合物单体MLABe和聚-β-羟基丁酸酯(PHB),为共聚奠定了基础.共聚实验结果表明,聚合物单体含量不同,聚合物组成有明显差别,分子量都在104以上.MLABe的竞聚率比BL的大,因此加入BL的比率越多,聚合时间就越长.MLABe和BL的比例为75/25(物质的量比),聚合时间短且共聚产物分子量适中,分布宽度窄.微观聚合机理表明MLABe和BL的比例为50/50(物质的量比)时,聚合过程酯交换剧烈,趋向于无规共聚.P(MLABe-co-BL)氢化苄基后得到两亲性共聚物聚(β-苹果酸-co-β-羟基丁酸酯)(P(MLA-co-BL)),该共聚物改善了PMLA用作药物载体降解快、负电性大的缺点,有望在生物医用材料等方面得到应用.
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