双乳液是一类多重乳状液体系,它具有保护物质并且可以控制这些物质从一个相释放到另一个相的能力.近年来这类乳液体系与传统微胶囊制备方法的结合在药物输送(如抗癌药物、激素等)、食品等领域得到了一定的应用,解决了传统微胶囊制备方法无法有效封装高度水溶性物质等问题.基于此,综述了双乳液体系与微胶囊制备方法结合延伸出的一些新方法,包括双乳液-复凝聚法、复乳溶剂挥发法以及膜乳化复乳法等;同时,评述了影响双乳液体系制备微胶囊的各种因素,展望了双乳液体系在农药微胶囊制备中的应用前景.
参考文献
| [1] | Yang Y;Gao Y.Preparation and in vivo evaluation of thienorphine-loaded PLGA microspheres.[J].Die Pharmazie,201010(10):729-732. |
| [2] | 胡剑青;郑智贤;朱海军;涂伟萍;王锋.W/O/W复相乳液法合成多元氮丙啶/聚酯微胶囊的研究及表征[J].材料研究学报,2010(6):619-624. |
| [3] | 杨剀舟;刘云;杨立芳;冷小京.长双歧杆菌BBMN68微胶囊的制备及其应用性评价[J].食品科学,2015(9):71-77. |
| [4] | Robert Langer;Nicholas A.Peppas.Advances in Bioaterials,Drug Delivery,and Bionanotechnology[J].AIChE Journal,200312(12):2990-3006. |
| [5] | Santos, Milla G.;Bozza, Fernanda T.;Thomazini, Marcelo;Favaro-Trindade, Carmen S..Microencapsulation of xylitol by double emulsion followed by complex coacervation[J].Food Chemistry,2015Mar.15(Mar.15):32-39. |
| [6] | Glaucia A. Rocha-Selmi;Aline C. Theodoro;Marcelo Thomazini;Helena M.A. Bolini;Carmen S. Favaro-Trindade.Double emulsion stage prior to complex coacervation process for microencapsulation of sweetener sucralose[J].Journal of food engineering,20131(1):28-32. |
| [7] | 宋远见;刘红芝;温相如;张芳;刘志安;裴冬生;宗志敏;魏贤勇.基于W/O/W溶剂挥发复乳法的载药纳米微球合成及其作用研究[J].化工新型材料,2011(9):59-61. |
| [8] | 罗宇燕;麦海燕;黎呐;金启星;黄小舟;张永明.复乳法及其改良法制备的干扰素PLGA微球载药释药特性的对比[J].中山大学学报（自然科学版）,2014(3):110-114. |
| [9] | Nabi-Meibodi, M.;Vatanara, A.;Najafabadi, A.R.;Rouini, M.R.;Ramezani, V.;Gilani, K.;Etemadzadeh, S.M.H.;Azadmanesh, K..The effective encapsulation of a hydrophobic lipid-insoluble drug in solid lipid nanoparticles using a modified double emulsion solvent evaporation method[J].Colloids and Surfaces, B. Biointerfaces,2013:408-414. |
| [10] | Xu, B.;Dou, H.;Tao, K.;Sun, K.;Lu, R.;Shi, W..Influence of experimental parameters and the copolymer structure on the size control of nanospheres in double emulsion method[J].Journal of Polymer Research,20111(1):131-137. |
| [11] | 张琦;王进美;王卫.复相乳液法中药微胶囊的制备与性能研究[J].陕西科技大学学报（自然科学版）,2010(1):46-49,53. |
| [12] | Yeo Y;Bellas E;Firestone W;Langer R;Kohane DS.Complex coacervates for thermally sensitive controlled release of flavor compounds[J].Journal of Agricultural and Food Chemistry,200519(19):7518-7525. |
| [13] | Glaucia A. Rocha-Selmi;Fernanda T. Bozza;Marcelo Thomazini;Helena MA Bolini;Carmen S. Favaro-Trindade.Microencapsulation of aspartame by double emulsion followed by complex coacervation to provide protection and prolong sweetness[J].Food Chemistry,20131/4(1/4):72-78. |
| [14] | Talita A. Comunian;Marcelo Thomazini;Ana Julia Gouvea Alves;Fernando Eustaquio de Matos Junior;Julio C. de Carvalho Balieiro;Carmen S. Favaro-Trindade.Microencapsulation of ascorbic acid by complex coacervation: Protection and controlled release[J].Food Research International,20131(1):373-379. |
| [15] | 乔吉超;胡小玲;管萍;赵亚梅;田威.药用微胶囊的制备[J].化学进展,2008(1):171-181. |
| [16] | 曹梅;管萍;胡小玲;陈晓佩.W/O/W复乳溶剂蒸发法制备微胶囊的影响因素及研究新进展[J].化学与生物工程,2009(09):1-6,10. |
| [17] | 王侃;张琰;苄卿卿;郎美东.BSA载药微囊的制备、表征及体外释放行为[J].功能高分子学报,2008(4):364-370. |
| [18] | 马爱洁;张玉祥;陈卫星.复相乳液法制备聚乳酸/胰岛素缓释微胶囊[J].西安工业大学学报,2009(4):341-344. |
| [19] | Hallaj Nezhadi S;Lotfipour F;Dass CR.Delivery of nanoparticulate drug delivery systems via the intravenous route for cancer gene therapy.[J].Die Pharmazie,201012(12):855-859. |
| [20] | 包德才;郑建华;赵燕军;马小军;袁权.膜乳化技术及其应用[J].化学通报（印刷版）,2006(4):241-246. |
| [21] | 谢锐;褚良银;陈文梅;肖新才;王枢.膜乳化法制备单分散高分子微球和微囊的研究进展[J].膜科学与技术,2004(4):61-65. |
| [22] | van der Graaf S;Schroen CGPH;Boom RM.Preparation of double emulsions by membrane emulsification - a review[J].Journal of Membrane Science,20051/2(1/2):7-15. |
| [23] | Ito F;Honnami H;Kawakami H;Kanamura K;Makino K.Preparation and properties of PLGA microspheres containing hydrophilic drugs by the SPG (shirasu porous glass) membrane emulsification technique[J].Colloids and Surfaces, B. Biointerfaces,20081(1):20-25. |
| [24] | Vladisavjevic GT;Shimizu M;Nakashima T.Preparation of monodisperse multiple emulsions at high production rates by multi-stage premix membrane emulsification[J].Journal of Membrane Science,20041/2(1/2):97-106. |
| [25] | 黄珊珊;刘荣;马光辉;谭天伟.膜乳化法与复乳法结合制备粒径均一的载溶菌酶微胶囊[J].过程工程学报,2006(4):603-607. |
| [26] | 赖波;卫强;孙春宝;马光辉;苏志国.膜乳化法与复乳法结合制备粒径均一的PELA载溶菌酶微球[J].过程工程学报,2008(2):327-332. |
| [27] | 王超宝;蔡静;郑业灿.膜乳化技术-复乳法制备载药微囊的研究[J].广州化工,2010(3):82-84. |
| [28] | 宋薇;马光辉;苏志国.复乳法制备大孔聚合物微球[J].过程工程学报,2007(5):1029-1034. |
| [29] | 冯晓健;吕秀玲;李学刚.改良复乳法（W/O/W）制备聚乳酸载药微球[J].河北理工大学学报(自然科学版),2010(2):90-93. |
| [30] | McClements, DJ;Decker, EA;Weiss, J.Emulsion-based delivery systems for lipophilioc bioactive components[J].Journal of Food Science,20078(8):R109-R124. |
| [31] | Yang YY;Chung TS;Ng NP.Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method.[J].Biomaterials,20013(3):231-241. |
| [32] | 潘小会;王进美;吴铁城.艾叶提取物驱蚊微胶囊的制备[J].合成纤维,2012(1):27-30,51. |
| [33] | 赵景联;陈庆云;王云海;黄建新.PHB-PEG共混物为载体药物缓释微球的研究[J].西安交通大学学报,2001(7):759-763. |
| [34] | Valentina Coccoli;Alessia Luciani;Silvia Orsi;Vincenzo Guarino;Filippo Causa;Paolo Antonio Netti.Engineering Of Poly(ε-caprolactone) Microcarriers To Modulate Protein Encapsulation Capability And Release Kinetic[J].Journal of Materials Science. Materials in Medicine,20084(4):1703-1711. |
| [35] | Lanny Sapei;Muhammad Ali Naqvi;Derick Rousseau.Stability and release properties of double emulsions for food applications[J].Food hydrocolloids,20122(2):316-323. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%