海藻酸钠纳米粒制备的研究进展?

材料导报, 2016, 30(5): 7-11. doi: 10.11896/j.issn.1005-023X.2016.05.002

海藻酸钠纳米粒制备的研究进展?

吴叶 ^1, , 刘袖洞 ^2, , 王云红 ^3, , 于炜婷 ^4, , 戴小敏 ^5, , 马小军 ^6,

1.大连大学环境与化学工程学院,大连,116622

2.大连大学环境与化学工程学院,大连,116622

3.大连大学环境与化学工程学院,大连,116622

4.中国科学院大连化学物理研究所,大连,116023

5.大连大学环境与化学工程学院,大连,116622

6.中国科学院大连化学物理研究所,大连,116023

基金项目: 辽宁省高等学校优秀科技人才支持计划(LR2013057) 辽宁省“十百千高端人才引进工程”启动基金(辽人社[2012]207号) 国家自然科学基金(21276033)

关键词：海藻酸钠 , 纳米粒 , 药物载体

Review on Preparation of Sodium Alginate Nanoparticles

Keywords： sodium alginate , nanoparticle , drug carrier

纳米粒药物载体能帮助药物靶向传输及可控释放，是生物医药领域的重要研究方向。海藻酸钠生物相容性好、易于修饰及加工形成微纳米颗粒，作为药物载体的应用研究日渐增多。综述了制备海藻酸钠纳米粒的4种方法，即离子交联法、乳化法、静电络合法和自组装法，并指出了4种方法的优缺点。

Nanoparticle-based drug carriers can realize the targeted transportation and controlled release of drugs,so it is an important research direction in biomedical areas.In view of the biocompatibility,easily being modi-fied and processed to micro-/nano-particles,sodium alginate has been gradually used to prepare nanoparticles for drug loading.Four main methods to prepare sodium alginate nanoparticles are summarized,that is,ionic crosslinking,e-mulsion,electrostatic complexation and self-assembly,and the advantages and disadvantages of the four methods are introduced.

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