羟基磷灰石（HA）成分与人体骨和牙齿相近，植入人体后，其羟基（-OH）与骨细胞形成化学键结合，具有良好的生物活性和生物相容性。主要介绍了羟基磷灰石涂层的热喷涂、激光熔敷和复合技术制备方法及特点，在临床使用案例基础上，从涂层的力学性能及生物活性两个方面总结涂层失效的原因。针对制备涂层结合强度、生物活性、化学稳定性等内在问题，给出了可行的解决方案，为高性能的 HA 涂层的制备和应用提供参考。
The composition of hydroxyapatite (HA)is similar to human bone and teeth.After implantation, the hydroxyl (-OH)will be chemically bonded with bone cells,thus HA exhibits good biological activity and biocom-patibility.This review focuses on preparation methods for hydroxyapatite coating,including thermal spraying,laser cladding and composite technique,as well as the corresponding coating characteristics.Based on clinical studies,the reasons for coating failure are summarized in terms of both mechanical properties and biological activity of coating.Ai-ming at the problems in coating bonding strength,biological activity and chemical stability,some possible solutions are provided for the preparation and application of HA coating.
参考文献
| [1] | 郑学斌;谢有桃.热喷涂生物陶瓷涂层的研究进展[J].无机材料学报,2013(1):12-20. |
| [2] | 朱庆霞;冯青;汪和平.羟基磷灰石涂层的制备及其研究进展[J].中国陶瓷,2008(3):34-38. |
| [3] | Mittal, M.;Nath, S.K.;Prakash, S..Improvement in mechanical properties of plasma sprayed hydroxyapatite coatings by Al2O3 reinforcement[J].Materials science & engineering, C. Materials for Biogical applications,20135(5):2838-2845. |
| [4] | Fei Weng;Chuanzhong Chen;Huijun Yu.Research status of laser cladding on titanium and its alloys: A review[J].Materials & design,2014Jun.(Jun.):412-425. |
| [5] | M. F. Morks;Akira Kobayashi;N. F. Fahim.Abrasive wear behavior of sprayed hydroxyapatite coatings by gas tunnel type plasma spraying[J].Wear: an International Journal on the Science and Technology of Friction, Lubrication and Wear,20071/2(1/2):204-209. |
| [6] | Zheng X;Huang M;Ding C.Bond strength of plasma-sprayed hydroxyapatite/Ti composite coatings.[J].Biomaterials,20008(8):841-849. |
| [7] | Ning CY;Wang YJ;Chen XF;Zhao NR;Ye JD;Wu G.Mechanical performances and microstructural characteristics of plasma-sprayed bio-functionally gradient HA-ZrO2-Ti coatings[J].Surface & Coatings Technology,20057(7):2403-2408. |
| [8] | S Yugeswaran;C P Yoganand;A Kobayashi;K M Paraskevopoulos;B Subramanian.Mechanical properties, electrochemical corrosion and in-vitro bioactivity of yttria stabilized zirconia reinforced hydroxyapatite coatings prepared by gas tunnel type plasma spraying.[J].Journal of the mechanical behavior of biomedical materials,2012:22-33. |
| [9] | Lahiri, D.;Ghosh, S.;Agarwal, A..Carbon nanotube reinforced hydroxyapatite composite for orthopedic application: A review[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20127(7):1727-1758. |
| [10] | 王勇;高家诚;张亚平.激光熔覆梯度生物陶瓷涂层的研究[J].中国激光,2004(4):487-490. |
| [11] | 吕晓卫;林鑫;关泰红;高勃;黄卫东.CaCO3和CaHPO4·2H2O粉末配比对激光熔覆原位合成羟基磷灰石涂层的影响[J].稀有金属材料与工程,2011(1):22-27. |
| [12] | F. Lusquinos;J. Pou;M. Boutinguiza;F. Quintero;R. Soto;B. Leon;M. Perez-Amor.Main characteristics of calcium phosphate coatings obtained by laser cladding[J].Applied Surface Science: A Journal Devoted to the Properties of Interfaces in Relation to the Synthesis and Behaviour of Materials,20051/4(1/4):486-492. |
| [13] | 邓迟;张亚平;高家诚;王远亮;王勇;戴彩云.激光熔覆生物陶瓷涂层温度场的数值模拟[J].材料科学与工程学报,2003(4):503-506. |
| [14] | Gary J. Cheng;Daniel Pirzada;M. Cai;Pravansu Mohanty;Amit Bandyopadhyay.Bioceramic coating of hydroxyapatite on titanium substrate with Nd-YAG laser[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20054(4):541-547. |
| [15] | 李志明;钱士强.激光重熔等离子喷涂涂层研究现状与展望[J].上海工程技术大学学报,2009(3):263-269. |
| [16] | 高亚丽;接勐;张海波.医用镁合金表面激光重熔羟基磷灰石涂层[J].材料热处理学报,2012(9):117-121. |
| [17] | ZHAO Guo-liang;WEN Guang-wu;WU Kun.Influence of processing parameters and heat treatment on phase composition and microstructure of plasma sprayed hydroxyapatite coatings[J].中国有色金属学报(英文版),2009(z2):463-469. |
| [18] | 鲍雨梅;高海明;许景顺;马龙;徐哲玉.激光熔覆生物陶瓷涂层物相分析[J].中国激光,2014(10):68-73. |
| [19] | Yang CW;Lee TM;Lui TS;Chang E.Effect of post vacuum heating on the microstructural feature and bonding strength of plasma-sprayed hydroxyapatite coatings[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20068(8):1395-1400. |
| [20] | Byung-Dong Hahn;Jeong-Min Lee;Dong-Soo Park;cJong-Jin Choi;Jungho Ryu;Woon-Ha Yoon <英文作者八>=Joon-Hwan Choi<英文作者九>=Byoung-Kuk Lee<英文作者十>=Jong-Woo Kim<英文作者十一>=Hyoun-Ee Kim.Enhanced bioactivity and biocompatibility of nanostructured hydroxyapatite coating by hydrothermal annealing[J].Thin Solid Films,201122(22):8085-8090. |
| [21] | Yi Huang;Yang Qu;Bangcheng Yang;Wei Li;Bo Zhang;Xingdong Zhang.In vivo biological responses of plasma sprayed hydroxyapatite coatings with anelectric polarized treatment in alkaline solution[J].Materials science & engineering, C. Biomimetic and supramolecular systems,20098(8):2411-2416. |
| [22] | 张素敏;徐婧;张亮;秦永清;王晓庆;曹波;杜晓曦;王晓晔.骨科植入物不良事件发生原因分析及预防措施：1309例可疑医疗器械不良事件报告分析[J].现代仪器,2011(3):36-38,35. |
| [23] | 王峰;陈东阳;邱旭升;徐志宏;王祖玉;史冬泉;蒋青.生物型髋关节假体涂层脱落的临床分期和预防[J].中国骨伤,2009(6):413-416. |
| [24] | Ahmed, A.;Mhaede, M.;Wollmann, M.;Wagner, L..Characteristics of sintered HA coating deposited by chemical method on AISI 316L substrate[J].Materials & design,2015Jul.(Jul.):9-17. |
| [25] | Cheng- Kuo Lee.Fabrication, characterization and wear corrosion testing of bioactive hydroxyapatite/nano-TiO_2 composite coatings on anodic Ti-6Al-4V substrate for biomedical applications[J].Materials Science & Engineering, B. Solid-State Materials for Advanced Technology,201211(11):810-818. |
| [26] | H. Li;K.A. Khor;P. Cheang.Adhesive and bending failure of thermal sprayed hydroxyapatite coatings: Effect of nanostructures at interface and crack propagation phenomenon during bending[J].Engineering Fracture Mechanics,200712(12):1894-1903. |
| [27] | 郭佳勇 .羟基磷灰石涂层髋关节假体的Meta分析[D].安徽医科大学,2014. |
| [28] | Yaser Ghani;Melanie J Coathup;Karin A Hing;Gordon W Blunn.Development of a hydroxyapatite coating containing silver for the prevention of peri-prosthetic infection.[J].Journal of orthopaedic research,20123(3):356-363. |
| [29] | 陈有应;耿彬;王金清;夏亚一;汪静.含氟、锌、银羟基磷灰石涂层的制备与结构表征[J].材料导报,2012(z1):267-269. |
| [30] | Alt V;Bitschnau A;Osterling J;Sewing A;Meyer C;Kraus R;Meissner SA;Wenisch S;Domann E;Schnettler R.The effects of combined gentamicin-hydroxyapatite coating for cementless joint prostheses on the reduction of infection rates in a rabbit infection prophylaxis model[J].Biomaterials,200626(26):4627-4634. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%