PGS/PLLA静电纺丝复合纳米纤维支架的性能研究

材料导报, 2016, 30(14): 67-97. doi: 10.11896/j.issn.1005-023X.2016.14.015

PGS/PLLA静电纺丝复合纳米纤维支架的性能研究

包广洁 ^1, , 钟妮 ^2, , 张文霞 ^3, , 李燕梅 ^4, , 吕玮 ^5, , 张树江 ^6, , 康宏 ^7,

1.西北民族大学口腔医学国家民委重点实验室,兰州730030;兰州大学口腔医学院,兰州730000

2.兰州大学口腔医学院,兰州,730000

3.兰州大学口腔医学院,兰州,730000

4.兰州大学口腔医学院,兰州,730000

5.兰州大学口腔医学院,兰州,730000

6.兰州大学化学化工学院,兰州,730000

7.兰州大学口腔医学院,兰州,730000

基金项目: 国家自然科学基金(81160139)

关键词： PGS , PLLA , 静电纺丝 , 三维纳米支架

Research on the Performance of PGS/PLLA Electrostatic Spinning of Composite Nanofiber Scaffold

Keywords： poly glycerol-sebacate , poly-L-lactic acid , electrospinning technique , three-dimensional scaffold

基于聚癸二酸丙三醇酯(PGS)优异的亲水性能,左旋聚乳酸(PLLA)良好的力学性能,以六氟异丙醇(HFIP)为溶剂,将PGS与PLLA按质量比1∶3、1∶1、3∶1配制成25％的纺丝液,采用静电纺丝技术制备了不同比例的新型三维纳米支架.通过扫描电镜、傅里叶红外光谱仪(FT-IR)、X射线衍射仪、热重分析仪、Instron微力试验机、接触角测量仪对共纺膜片进行表征.结果表明共纺膜片分布均匀,交织成网状;共纺膜片中加入PLLA对PGS聚合物结构几乎没有影响;随着PGS含量增加,结晶度呈增强趋势;伴随PLLA质量增加,热稳定性也趋于稳定;加入PGS,PGS/PLLA共纺膜片获得较好的亲水性,支架力学性能也得到改善;PGS/PLLA三维支架和山羊颞下颌关节盘细胞共培养,结果表明关节盘细胞在不同比例支架上粘附、铺展均良好,且在PGS/PLLA(1/3)膜片上生长较好.

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