随着纳米医学的发展,具有控制释放药物和生物活性分子、靶向刺激响应生理环境的聚合物纳米载体成为该领域活跃而具潜力的研究方向.超支化聚缩水甘油醚因其特定的三维结构、良好的亲水性、生物相容性和可修饰性而引起生物材料界的广泛关注.而经功能化修饰的超支化聚缩水甘油醚还可自组装成胶束、囊泡等药物载体或共价偶联成大分子前药.本文从超支化聚缩水甘油醚的疏水两亲修饰、环境敏感性功能化和超分子组装体改性三方面综述了功能化修饰的超支化聚缩水甘油醚在药物载体领域的研究进展.并系统归纳了超支化聚缩水甘油醚两亲功能化、环境敏感功能化的分子设计策略.另外,对基于环糊精主客体作用的超支化超分子聚缩水甘油醚共聚物的组装行为进行了简述.
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