溴酸钠和氯化铁为助催化剂2,2,6,6-四甲基-N-氧化哌啶催化醇的氧化

应用化学, 2015, 32(6): 666-670. doi: 10.11944/j.issn.1000-0518.2015.06.140331

溴酸钠和氯化铁为助催化剂2,2,6,6-四甲基-N-氧化哌啶催化醇的氧化

褚朝森 ^1, , 王晓丽 ^2, , 胡玉涛 ^3, , 闫秀美 ^4, , 王政 ^5,

1.江苏联合职业技术学院连云港中医药分院;连云港市药物研发共性技术中心

2.江苏联合职业技术学院连云港中医药分院

3.江苏联合职业技术学院连云港中医药分院

4.江苏德源药业有限公司江苏连云港222047

5.江苏德源药业有限公司江苏连云港222047

基金项目: 连云港市药物研发共性技术中心科技项目(2013-2015) High Vels of Demonstration Bases Construction Project in Jiangsu Province(2013-2014) 江苏省高水平示范性实训基地建设项目专项经费资助(2013-2014) Qinglan Project of Jiangsu Province(2014) Lianyungang Common Technological Center for Druug Research and Development(2013-2015) 江苏省“青蓝工程”培养基金(2014)

关键词：四甲基-N-氧化哌啶 , 溴酸钠 , 醇 , 氧化

Catalyzed Oxidation of Alcohols by 2,2,6,6-Tetramethyl-1-iperidinyloxy with Sodium Bromate and Ferric Chloride as Accelorators

Keywords： tetramethyl-piperidinyloxy , sodium bromate , alcohol , oxidation

建立了溴酸钠和氯化铁为助催化剂2,2,6,6-四甲基-N-氧化哌啶(NaBrO3-FeCl3-TEMPO)新型催化体系,以苯甲醇的氧化为研究对象,得出各成分与底物的最佳物质的量比为:2％ TEMPO、35％ NaBrO3、3.7％H2SO4、2％FeCl3·6H2O.该体系在室温下可有效实现芳香醇、脂肪醇及杂环醇的氧化,收率高(99％)、选择性强(99％),在无氧条件下,仍表现出较好的催化活性.

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