以二肽Pro-Trp为催化剂,2,3,4,5,6,6-六氯-2,4-环己二烯-1-酮为氯化剂,离子液体Zn[CO(NH2)2]3Cl2为溶剂,在N-甲基吗啉(NMM)存在下,各种醛能够高收率、较高立体选择性地完成羰基α-卤代反应,目标产物的产率可达到95％,对映选择性可达92％ ee.该方法具有操作简便、离子液体和催化剂可重复使用的优点.
参考文献
| [1] | 赵地顺;李雪刚;刘宝友;徐智策;王娜.离子液体体系ZnCl2-尿素的制备及性质[J].精细化工,2007(7):632-635. |
| [2] | Liang Wang;Chun Cai;DennisP.Curran;Wei Zhang.Enantioselective α-Chlorination of Aldehydes with Recyclable Fluorous(S)-Pyrrolidine–Thiourea Bifunctional Organocatalyst[J].Synlett,20103(3):433-436. |
| [3] | Welton Thomas.Room-Temperature lonic Liquids.Solvents for Synthesis and Catalysis[J].Chemical Reviews,19998(8):2071-2083. |
| [4] | Marigo M;Jorgensen KA.Organocatalytic direct asymmetric alpha-heteroatom functionalization of aldehydes and ketones[J].Chemical communications,200619(19):2001-2011. |
| [5] | Nis Halland;Alan Braunton;Stephan Bachmann;Mauro Marigo;Karl Anker Jorgensen.Direct Organocatalytic Asymmetric -Chlorination of Aldehydes[J].Journal of the American Chemical Society,200415(15):4790-4791. |
| [6] | Michael P.Brochu;Sean P.Brown;David W.C.MacMillan.Direct and Enantioselective Organocatalytic alpha-Chlorination of Aldehydes[J].Journal of the American Chemical Society,200413(13):4108-4109. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%