设计并合成了22个具有长脂肪链取代的新型三唑曼尼希碱,研究了其植物生长调节活性、除草活性和对细胞周期分裂蛋白25B(CDC25B)抑制活性,结果发现,多数目标分子表现出优良的促进细胞生长素活性和除草活性,表明该类分子有望成为优良的新型农药;对CDC25B抑制活性筛选发现一种曼尼希碱具有优良的CDC25B抑制活性,其IC50值低于阳性参照物正钒酸钠,有望成为肿瘤治疗的药物先导物.
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