发展了一种可见光诱导的活泼烯烃串联自由基环化合成含氟异喹啉二酮的反应.在可见光诱导下,多种N-烷基-N-甲基丙烯酰基苯甲酰胺与二氟溴乙酸乙酯发生自由基串联环化反应,以66％～75％的产率合成了一系列具有潜在生理活性的二氟烷基化异喹啉二酮.此研究为合成具有潜在药用价值的氟取代异喹啉二酮提供了一条高效、条件温和的途径.
参考文献
| [1] | Purser S;Moore PR;Swallow S;Gouverneur V.Fluorine in medicinal chemistry[J].Chemical Society Reviews,20082(2):320-330. |
| [2] | Prakash GS;Chacko S.Novel nucleophilic and electrophilic fluoroalkylation methods.[J].Current opinion in drug discovery & development,20086(6):793-802. |
| [3] | Yi-Hua Chen;Ya-Hui Zhang;Hua-Jie Zhang;Da-Zhi Liu;Min Gu.Design,Synthesis,and Biological Evaluation of Isoquinoline-l,3,4-trione Derivatives as Potent Caspase-3 Inhibitors[J].Journal of Medicinal Chemistry,20065(5):1613-1623. |
| [4] | Beatrice Quiclet-Sire;Samir Z. Zard.An expedient synthesis of homophthalimides[J].Chemical communications,200220(20):2306-2307. |
| [5] | 唐裕才;张敏;李小青;许响生;杜晓华.四丁基碘化胺催化活化烯烃烷氧羰基化反应：合成异喹啉二酮衍生物[J].有机化学,2015(4):875-881. |
| [6] | Fu, Weijun;Zhu, Mei;Zou, Guanglong;Xu, Chen;Wang, Zhiqiang.Visible-Light-Mediated Radical Aryldifluoroacetylation of N-Arylacrylamides to give Difluoroacetylated Oxindoles[J].Asian Journal of Organic Chemistry,201412(12):1273-1276. |
| [7] | Fu, Weijun;Zhu, Mei;Zou, Guanglong;Xu, Chen;Wang, Zhigiang;Ji, Baoming.Visible-Light-Mediated Radical Aryldifluoroacetylation of Alkynes with Ethyl Bromodifluoroacetate for the Synthesis of 3-Difluoroacetylated Coumarins[J].The Journal of Organic Chemistry,20159(9):4766-4770. |
| [8] | Xu, Pan;Hu, Kaidong;Gu, Zhangxi;Chenga, Yixiang;Zhu, Chengjian.Visible light promoted carbodifluoroalkylation of allylic alcohols via concomitant 1,2-aryl migration[J].Chemical communications,201533(33):7222-7225. |
| [9] | 周栋;李玉花;邓佑林;李志豪;唐石.自由基介导C-H键环化合成吲哚酮的研究进展[J].吉首大学学报（自然科学版）,2015(2):60-70. |
| [10] | Zheng, Lewei;Yang, Chao;Xu, ZhaoZhong;Gao, Fei;Xia, Wujiong.Difunctionalization of Alkenes via the Visible-Light-Induced Trifluoromethylarylation/1,4-Aryl Shift/Desulfonylation Cascade Reactions[J].The Journal of Organic Chemistry,201511(11):5730-5736. |
| [11] | Zhang, Min;Xie, Ping;Zhao, Wannian;Niu, Ben;Wu, Wei;Bian, Zhaogang;Pittman, Charles U., Jr.;Zhou, Aihua.Cascade Couplings of N-Alkyl-N-methacryloyl Benzamides with Ethers and Benzenesulfonohydrazides To Generate Isoquinoline-1,3(2H,4H)-dione Derivatives[J].The Journal of Organic Chemistry,20158(8):4176-4183. |
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