可见光诱导烯烃串联加成环化合成多氟烷基化异喹啉二酮

应用化学, 2016, 33(6): 685-692. doi: 10.11944/j.issn.1000-0518.2016.06.150317

可见光诱导烯烃串联加成环化合成多氟烷基化异喹啉二酮

邓佑林 ^1, , 唐石 ^2, , 张倩 ^3, , 王琼 ^4, , 彭梦璐 ^5, , 于丽敏 ^6,

1.吉首大学化学化工学院湖南吉首416000

2.吉首大学化学化工学院湖南吉首416000

3.吉首大学化学化工学院湖南吉首416000

4.吉首大学化学化工学院湖南吉首416000

5.吉首大学化学化工学院湖南吉首416000

6.吉首大学化学化工学院湖南吉首416000

基金项目: 湖南省高校科技创新团队支持计划“环境能源材料与武陵山区矿产资源精深加工”资助,吉首大学校级科研项目资助(15JDY001) Aid Program(Environment and Energy Materials and Deep Processing of Mineral Resources in Wuling Mountain) for Science and Technology Innovative Research Team in Higher Educational Instituions of Hunan Province,the School-level Scientific Research Project of Jishou University(15JDY001) 国家自然基金资助项目(21462017) the National Natural Science Foundation of China(21462017)

关键词：可见光诱导 , C-H环化 , 全氟烷基碘 , 多氟取代异喹啉二酮

Visible-light-induced Cascade Addition Cyclization of Alkenes Toward Perfluoroalkylated Isoquinolinediones

Keywords： visible-light-induced , C-H cyclization , perfluoroalkyl iodides , perfluorinated isoquinolinedione

发展了一种可见光诱导的活泼烯烃与全氟碘代烷串联加成环化合成多氟异喹啉二酮的反应.在可见光诱导下,多种N-丙烯酰基-N-丁基苯甲酰胺衍生物与全氟碘代烷发生自由基串联加成环化反应,以54％～80％的产率合成了一系列的多氟取代异喹啉二酮衍生物.为具有潜在药用价值的多氟取代异喹啉二酮合成提供了一条高效、条件温和、绿色的新途径.

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