根据仿生学原理,以纳米β-磷酸三钙颗粒(nano β-TCP)、胶原(Col)与硫酸软骨素(CS)为原材料通过热脱氢交联(DHT)-碳化二亚胺(EDC)复合改性制备了纳米β-磷酸三钙-胶原/硫酸软骨素(nano β-TCP-Col/CS)支架复合材料,利用XRD和AFM分析nano β-TCP-Col/CS支架复合材料的微观结构,并进一步采用SEM、XPS、TG和在模拟体液(SBF)中的矿化与降解实验等分析手段对nano β-TCP-Col/CS支架复合材料的结构与性能进行表征.结果表明:所用β-TCP晶体的平均尺寸为41.3 nm,属纳米级;nano β-TCP-Col/CS支架复合材料中nano β-TCP与Col、CS之间具有较强的相互作用;nano β-TCP-Col/CS复合材料具有较高的稳定性、一定的矿化生物活性以及适宜的生物降解性,是一种潜在的口腔修复材料.
Based on the theory of bionics,nano β-tricalcium phosphate-collagen/chondroitin sulfate (nano β-TCP-Col/CS) scaffold composites were modified by dehydrathermal (DHT) and 1-Ethyl-3-(3-Dimethylaminopropyl) (EDC) using nano β-tricalcium phosphate (nano β-TCP),collagen (Col) and chondroitin sulfate (CS) as the raw materials.The structure and properties of nano β-TCP-Col/CS scaffold composites were investigated by XRD,AFM,SEM,XPS,TG and degradation and mineralization in simulated body fluid (SBF).The results indicate that the size of β-TCP is 41.3nm.Due to a strong interaction among nano β-TCP,Col and CS,nano β-TCP-Col/CS scaffold composites has strong stability,mineralized biological activity and appropriate biodegradability,which is a kind of potential dental restorative materials.
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