利用碳酸钙模板和离子交换过程成功制备了一种新型掺铕羟基磷灰石微球.通过扫描电子显微镜(SEM)、X射线衍射(XRD)、感应耦合等离子体(ICP)、光致发光谱和体外MTT实验对微球物化性能、发光性和细胞毒性进行了表征.研究结果显示:掺铕羟基磷灰石微球呈椭球形,直径约为2.5 μm,长度约为7μm,并具有刺猬状表面;在晶体结构上与纯相六方羟基磷灰石相同,具有高结晶性;铕离子成功进入羟基磷灰石晶相.同时,研究还表明该掺铕羟基磷灰石颗粒在紫外光激发下显示出红色荧光.光致发光光谱表明铕离子的5D0--7F1-4跃迁明显在光致发光活性中具有重要作用.体外细胞毒性实验结果显示:MC3T3-E1小鼠胚胎骨细胞在掺铕羟基磷灰石浸提液中能够持续增殖,没有细胞形态上的变化,并且细胞相对增值率计算结果表明该掺铕羟基磷灰石细胞毒性等级为1级.
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