欢迎登录材料期刊网

材料期刊网

高级检索

利用低温等离子体技术在用于膜式人工肺的聚砜(PSf)中空纤维膜表面接枝丙烯酸(AA)和肝素,通过改性以提高膜材料的血液相容性.通过改性前后膜的接触角及接枝率测试结果比较,得出优化的改性条件,即选用氩气(Ar)作为等离子体气源,处理功率为40 W及处理时间为60s.改性后膜材料对牛血清白蛋白(BSA)及血小板黏附量显著减少.此外模拟人工肺进行气液双侧传输测试的结果表明,改性后膜材料保持了初始膜优良的气体传输性能,基本符合常见临床膜式人工肺标准.

参考文献

[1] Blanco JF;Sublet J;Nguyen QT;Schaetzel P .Formation and morphology studies of different polysulfones-based membranes made by wet phase inversion process[J].Journal of Membrane Science,2006(1/2):27-37.
[2] 俞三传;金可勇;高从堦 .高性能聚砜支撑膜研制[J].膜科学与技术,1999,19(6):45-47,55.
[3] Ota K .Advances in artificial lungs[J].Journal of Artificial Organs,2010,13(1):13-16.
[4] 王丽红,陈欢林.改善生物医用高分子膜表面血液相容性的PC技术[J].膜科学与技术,2006(03):90-94.
[5] Grace J M;Gerenser L J .Plasma Treatment of Polymers[J].J Disperion Sci Technol,2003,24(3/4):305-341.
[6] 陈剑,李继定,王鼎,赵之平,陈翠仙.低温等离子体接枝改性PVDF膜[J].膜科学与技术,2007(01):23-26,31.
[7] Akamatsu K;Furue T;Han F et al.Plasma graft polymerization to develop low-fouling membranes grafted withpoly(2-methoxyethylacrylate)[J].Sep Perif Technol,2013,102(4):157-162.
[8] Taraballi F;Zanini S;Lupo C .Amino and carboxyl plasma functionalization of collagen films for tissue engineering applications[J].Journal of Colloid and Interface Science,2013,394(15):590-597.
[9] Kara F;Aksoy E A;Yuksekdag Z et al.Synthesis and surface modification of polyurethanes with chitosan for antibacterial properties[J].Carbohydrate Polymers,2014,112(4):39-47.
[10] 吕权,殷海燕,虞文魁,黄鑫,李磊.膜式氧合器中聚砜非对称膜的制备及表征[J].膜科学与技术,2013(05):25-29,53.
[11] Liu Z M;Xu Z K;Wang J Q et al.Surface modification of microporouspolypropylene membranes by the grafting ofpoly(γ-stearyl-L-glutamate)[J].European Polymer Journal,2003,39(12):2291-2299.
[12] Zhu L P;Jiang J H;Zhu B K et al.Immobilization of bovine serum albumin onto porous polyethylene membranes using strongly attached polydopamine as a spacer[J].Coll Surf B,2011,86(1):111-118.
[13] 殷海燕,刘耀东,黄鑫,吕权,虞文魁,李磊.聚砜膜的低温等离子体改性及其在膜式氧合器的应用[J].膜科学与技术,2014(04):50-55.
[14] (R)ihová R .Biocompatibility of biomaterials:hemocompatibility,immunocompatiblity and biocompatibility of solid polymeric materials and soluble targetable polymeric carriers[J].Advanced Drug Delivery Reviews,1996,21(2):157-176.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%