在制备聚乳酸-聚乙二醇-聚乳酸(PLA-PEG-PLA)嵌段共聚物的基础上,以丙烯酸酯封端制备了PLA-PEG-PLA大分子单体.PLA-PEG-PLA大分子单体作为交联剂与N-乙烯基吡咯烷酮(NVP)单体经光聚合制备了系列PLA-PEG-PLA/PVP交联共聚物膜.核磁共振测试结果表明了大分子单体的成功合成;随着NVP投料量的增加,交联共聚物膜的亲水性增强,水解降解性加快,而储能模量(E’)及玻璃化转变温度(Tg)下降;NVP与PLA-PEG-PLA大分子单体的投料量由0.25/1.68(质量比)增至1.55/1.68时,共聚膜的拉伸强度由32.7 MPa降为17.1 MPa,而断裂伸长率由82％增至387％,说明共聚物膜的韧性较好.
On the basis of synthesis of acrylate-terminated poly(lactide)-poly(ethylene glycol)-poly(lactide) (PLA-PEG-PLA) macromer,a series of PLA-PEG-PLA/PVP crosslinked eopolymer films were prepared via photopolymerization of PLA-PEG-PLA rnacromer as crosslinker and N-vinylpyrrolidone (NVP).The structure of the macromer was confirmed by nuclear magnetic resonance (1H-NMR).With increase of the NVP amount incorporated,the hydrophilicity and hydrolytic degradation of the crosslinked copolmer films are improved,while the storage modulus (E') and glass transition temperature (Tg) are decreased.Mechanical measurements show that the tensile strength of crosslinked copolymer films is decreased from 32.7 MPa to 17.1 MPa,while the elongation at break is increased from 82 ％ to 387 ％,when the feed ratio of m (NVP)/m (PLA-PEG-PLA) macromer is changed from 0.25/1.68 to 1.55/1.68,indicating that copolymer films have high flexibility.
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