对等离子喷涂HA/Ti复合涂层进行模拟体液和体外细胞试验,以考察涂层的生物学性能.结果指出,涂层经模拟体液浸泡后,表面覆盖一层碳酸磷灰石(carbonate-apatite),这表明涂层具有良好的生物活性.粗糙的涂层表面易于形成碳酸磷灰石.模拟体液的浓度太小或pH值太大,均会导致碳酸磷灰石层不能在涂层表面形成.体外细胞试验显示,成骨细胞能在涂层表面紧密贴壁并正常生长,显示涂层具有优良的生物相容性.
SBF test and cell culture in vitro were carried out to evaluate the biological properties of plasma sprayed HA/Ti composite coatings. Results obtained show that the coating surfaces will be covered by carbonate-apatite layer after being immersed in SBF for 1 day, which indicate that the composite coatings possess good bioactivity. Carbonate-apatite layer is inclined to form on the rougher coating surface. Low concentration and high pH value of SBF are harmful to the formation of carbonate-apatite layer. Excellent biocompatibility of the composite coatings can be confirmed by osteoblasts attaching firmly and growing well on the coating surface.
参考文献
[1] | Groot K, Wolke J G C, Jansen J A. Proc. Instn Mech. Engrs. (Part H), 1998, 212: 137-147. |
[2] | Kurzweg H, Heimann R B, Troczynski T. J. Mater. Sci.: Mater. In Med., 1998, 9: 9-16. |
[3] | 郑学斌,丁传贤( ZHENG Xue-Bin,et al.无机材料学报(Journal of Inorganic Materials),2000,15(5):897-902. |
[4] | Chang E, Chang W J, Wang B C, et al. J. Mater. Sci.: Mater. In Med., 1997, 8: 201-211. |
[5] | Kirkpatrick C J, Bittinger F, Wagner M, et al. Proc. Instn Mech. Engrs. (Part H), 1998, 212:75-84. |
[6] | Wen H B, Wolke J G C, Wijn J R, et al. Biomaterials, 1997, 18 (22): 1471-1478. |
[7] | Heimann R B, Kurzweg H, Vu T A. In: Coddet C. ed. Proceeding of the 15th international thermal spray conference (France). USA: ASM International, 1998. 999-1003. |
[8] | Kokubo T, Miyaki F, Kim H, et al. J. Am. Ceram. Soc., 1996, 79: 1127-1129. |
[9] | Kim H M, Miyaji F, Kokubo T, et al. J. Am. Ceram. Soc., 1995, 78: 2405-2411. |
[10] | Weng J, Liu Q, Wolke J G C, et al. Biomaterials, 1997, 18 (15): 1027-1035. |
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