采用溶媒投放、颗粒滤取技术制备出CPP/PLLA软骨组织工程支架复合材料,测试了该复合材料的物理力学性能和降解性能.研究结果表明,CPP/PLLA软骨组织工程支架复合材料具有高的孔隙率(90%)、良好的生物降解性能和物理力学性能,以及三维连通、微L、网状微观结构,故该复合材料有希望成为软骨组织工程支架材料之一.
参考文献
[1] | Thomson R C,Wake M C, Yaszemski M J, et al. Biodegradable polymer scaffolds to regenerate organs [J]. Adv Polymer Sci, 1995,122(3): 245-274. |
[2] | Freed L E, Vanjak-Novokovic L, Biron R J, et al. Biodegrad able polymer scaffolds for tissue engineering [J]. Bio-technology,1994,12(7): 689-693. |
[3] | Temenoff J S, Mikes A G. Tissue engineering for regeneration of articular cartilage [J]. Bio-materrials, 2000,21(3) :431- 440. |
[4] | Kim B S, Mooney D I. Development of biocompatible synthetic extracellular matrices for tissue engineering [J]. Trends Bio technology,1998,16(5): 224-230. |
[5] | Grande D A, Habberstadt C, Naughton G, et al. Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts [J]. JBiomedMaterRes, 1997,34(3) : 211 220. |
[6] | Martin Z, Ouarto R, Dozin B, et al. Producing prefabricated tissues and organs via tissue engineering [J]. IEEE Eng Med Biol, 1997,16(2):73-80. |
[7] | Cur F Z, Zhu X D. Three dimensional nano Hap/collagen ma trix loading with osteogenic cells in organ culture [J].J Biomed Mater Res, 1999,44(3): 407-415. |
[8] | 石宗利,戴刚,李重庵,等.一种新型软骨组织工程材料CPP纤维的制备和性能[J].兰州大学学报,2001,37(2):47-51. |
[9] | Freed L E, Marquis J C, Nohria A, et al. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymer [J ]. J Biomed Mater Res, 1993,27 (1): 11-23. |
[10] | Mikos A G, Thorsen A J, Gzerwonka L A,et al. Preparationand characterization of poly (L-Lactic acid) foams [J]. Polyer, 1994,35 :1068- 1077. |
[11] | Holy C E, Dang S M, et al. In vitro degradation of a novel poly (Lactide-co-glycolide) 75/25 foam [J]. Bio-materials, 1999,20:1177-1185. |
[12] | 王兴业,唐羽章.复合材料力学性能[M].北京:国防科技大学出版社,1988. |
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