对适用于人体承重部位的人工种植体羟基磷灰石-二氧化锆生物复合材料的制备工艺、微观结构及生物相容性进行了初步研究.用扫描电镜(SEM)、X射线衍射(XRD)和透射电镜(TEM)对粉体和复合材料进行分析.用体外检测复合材料浸提液对健康青年人末梢血单个核细胞(PBMC)的激活来评价其免疫相容性.结果表明:1600℃无压烧结3h后的复合材料表面层主晶相为β-Ca3(PO4)2(β-TCP)、α-Ca3(PO4)2(α-TCP)和CaZrO3相.单纯复合材料和梯度复合材料的表面粗糙度分别为3.12 μm和1.95 μm.其弯曲强度分别为732.85 MPa和689.04 MPa.HA/ZrO2复合材料具有免疫相容性,梯度复合材料的免疫相容性优于单纯复合材料.
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