人类基因组的单核苷酸多态性及其研究进展

色谱 , 2003, 21(2): 110-114. doi: 10.3321/j.issn:1000-8713.2003.02.004

人类基因组的单核苷酸多态性及其研究进展

赵春霞 ^1, , 石先哲 ^2, , 吕申 ^3, , 马坚妹 ^4, , 杨青 ^5, , 许国旺 ^6,

1.中国科学院大连化学物理研究所,辽宁,大连,116011

2.中国科学院大连化学物理研究所,辽宁,大连,116011

3.中国科学院大连化学物理研究所,辽宁,大连,116011;大连医科大学,辽宁,大连,116023

4.大连医科大学,辽宁,大连,116023

5.中国科学院大连化学物理研究所,辽宁,大连,116011

6.中国科学院大连化学物理研究所,辽宁,大连,116011

基金项目: 中国科学院知识创新工程项目(DICPK2001A4)

关键词：人类基因组 , 单核苷酸多态性 , 检测技术 , 医学应用 , 综述

Recent Advances in Single Nucleotide Polymorphism of Human Genome Research

对单核苷酸多态性(SNP)的概念及特性作了简要说明,介绍了14种检测SNP的方法,讨论了各种方法的原理及优缺点,并对目前SNP在遗传图的绘制、遗传病致病基因的搜寻、药物设计及法医学等方面的应用及其研究进展进行了综述.引用文献29篇.

参考文献

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人类基因组的单核苷酸多态性及其研究进展

Recent Advances in Single Nucleotide Polymorphism of Human Genome Research

参考文献