采用液相色谱-质谱联用方法分析了中药大黄经过SD大鼠肝匀浆体外代谢前后的指纹谱中色谱峰面积、保留值的差异.指出5种游离型蒽醌化合物在SD大鼠肝匀浆体外代谢体系中只有大黄酚发生代谢反应转化为芦荟大黄素.考察了体外代谢条件下,肝匀浆浓度与代谢时间对大黄酚转化及其代谢产物的影响.SD大鼠体外抗肿瘤试验表明,大黄代谢物对于人宫颈癌(HeLa)细胞的抑制活性略高于其提取物.通过比较芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚的活性,并结合大黄酚的体外代谢反应的考察,解释了大黄代谢物对肿瘤细胞活性的抑制率的提高是由大黄酚的代谢产物芦荟大黄素浓度的增加引起的.
参考文献
[1] | Xu Xiang, Li Baiping, Zhang Huifen. Shanghai Journal of Traditional Chinese Medicine (徐翔, 郦柏平, 张慧芬. 上海中医药杂志), 2003, 37(4): 56 |
[2] | Tsai T H, Chen C F. Asia Pac J Pharmacol, 1992, 7(1): 53 |
[3] | Liang J W, Hsiu S L, Huang H C, Lee-Chao P D. J Food Drug Anal, 1993, 1: 251 |
[4] | Shangguan Jie. Journal of Chinese Clinical Medicine (上官杰. 中华临床医药), 2003, 4(3): 79 |
[5] | Chang L C, Sheu H M, Huang Y S, Tsai T R, Kuo K W. Biochem Pharmacol, 1999, 58(1): 49 |
[6] | Yin Jian, Guo Ligong. Modern Study of Traditional Chinese Medicine and Clinical Application. Part Ⅰ. Beijing: Xue Yuan Press (阴健, 郭力弓. 中药现代研究与临床应用(Ⅰ). 北京: 学苑出版社), 1993. 61 |
[7] | Chen Qionghua, Zhao Yongquan, Li Diandong. Acta Pharmaceutica Sinica (陈琼华, 赵永荃, 李电东. 药学学报), 1966, 13(5): 363 |
[8] | Li Xiucai. Chinese Pharmaceutical Journal (李秀才. 中国药学杂志), 1998, 33(10): 581 |
[9] | Chen Qionghua. Information on Metallurgical Medicine (陈琼华. 冶金医药情报), 1990, 7(3): 88 |
[10] | Zhu Feng, Liu Xinguang, Liang Nianci. Chinese Journal of Cancer (朱峰, 刘新光, 梁念慈. 癌症), 2003, 22(4): 358 |
[11] | Wang H H, Chung J G, Ho C C, Wu L T, Chang S H. Planta Med, 1998, 64(2): 176 |
[12] | Huang Zhaosheng, Wang Zongwei. Foreign Medical Sciences: TCM Section (黄兆胜, 王宗伟. 国外医学·中医中药分册), 1997, 19(5): 9 |
[13] | Sun Yang, Chen Qionghua. Acta Pharmaceutica Sinica (孙阳, 陈琼华. 药学学报), 1986, 21(10): 748 |
[14] | Ou Ning, Gu Jinhua, Dong Qun. Chinese Traditional Patent Medicine (欧宁, 顾进华, 董群. 中成药), 1993, 15(7): 8 |
[15] | Jiang Xinhui, Zhang Dan, Chen Shujie. Chinese Journal of Chromatography (蒋心惠, 张丹, 陈淑杰. 色谱), 2003, 21(3): 251 |
[16] | Liang J W, Hsiu S L, WU P P, Chao P D L. Planta Med, 1995, 61(5): 406 |
[17] | Mueller S O, Stopper H, Dekant W. Drug Metab Dispos, 1998, 26(6): 540 |
[18] | Raleigh S M, Wanogho E, Burke M D, Mckeown S R, Patterson L H. Int J Radiat Oncol Biol Phys, 1998, 42(4): 763 |
[19] | Kong Liang. [PhD Thesis]. Dalian: Dalian Institute of Chemical Physics, The Chinese Academy of Sciences (孔亮. [博士学位论文]. 大连: 中国科学院大连化学物理研究所), 2005. 53 |
[20] | Dogterom P. Drug Metab Dispos, 1993, 21(4): 699 |
[21] | Shanghai Institute of Materia Medica, CAS. The Separation and Purification of Active Principles in Chinese Herbal Medicine. Shanghai: Shanghai Scientific & Techincal Publishers (中国科学院上海药物研究所. 中草药有效成分提取与分离. 上海: 上海科学技术出版社), 1983. 329 |
[22] | Hu Jun, Tu Pengfei, Guo Dean, Zheng Junhua. Northwest Pharmaceutical Journal (胡军, 屠鹏飞, 果德安, 郑俊华. 西北药学杂志), 1997, 12(4): 153 |
[23] | Hong Xiaokun, Wang Zhihua. The Digital Chromatographic Fingerprint of Traditional Chinese Medicine. Shanghai: Shanghai Scientific & Techincal Publishers (洪筱坤, 王智华. 中药数字化色谱指纹谱. 上海: 上海科学技术出版社), 2003. 66 |
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