用于高效液相色谱的不同形式的多孔整体固定相

色谱 , 2005, 23(6): 585-594. doi: 10.3321/j.issn:1000-8713.2005.06.005

用于高效液相色谱的不同形式的多孔整体固定相

基金项目: the Materials Sciences and Engineering Division of the U.S. Department of Energy(DE-AC02-05CH11231) the National Institute of General Medical Sciences, National Institutes of Health(GM-48364)

Porous Monoliths: Stationary Phases of Choice for High Performance Liquid Chromatography in Various Formats

Keywords： high performance liquid chromatography

Modern porous monoliths have been conceived as a new class of stationary phases for high performance liquid chromatography (HPLC) in classical columns in the early 1990s and later extended to the capillary format. These monolithic materials are prepared using simple processes carried out in an external mold (inorganic monoliths) or within the confines of the column (organic monoliths and all capillary columns). These methods afford macroporous materials with large through-pores that enable applications in a rapid flow-through mode. Since all the mobile phase must flow through the monolith, the convection considerably accelerates mass transport within the monolithic separation medium and improves the separations. As a result, the monolithic columns perform well even at very high flow rates. The applications of monolithic capillary columns are demonstrated on numerous separations in the HPLC mode.

参考文献

[1]	Meyers J J, Liapis A I. J Chromatogr A, 1999, 852: 3
[2]	Leinweber F C, Lubda D, Cabrera K, Tallarek U. Anal Chem, 2002, 74: 2 470
[3]	Kubin M, Spacek P, Chromecek R. Coll Czechosl Chem Commun, 1967, 32: 3 881
[4]	Ross W D, Jefferson R T. J Chrom Sci, 1970, 8: 386
[5]	Hileman F D, Sievers R E, Hess G G, Ross W D. Anal Chem, 1973, 45: 1 126
[6]	Svec F, Tennikova T B, Deyl Z. Monolithic Materials: Preparation, Properties, and Applications. Amsterdam: Elsevier, 2003
[7]	Zou H F, Huang X D, Ye M L, Luo Q Z. J Chromatogr A, 2002, 954: 5
[8]	Svec F. J Sep Sci, 2004, 27: 1 419
[9]	Mistry K, Grinberg N. J Liq Chromatogr, 2005, 28: 1 055
[10]	Nakanishi K, Soga N. J Am Ceram Soc, 1991, 74: 2 518
[11]	Tanaka N, Ishizuka N, Hosoya K, Kimata K, Minakuchi H, Nakanishi K, Soga N. Kuromatogurafi, 1993, 14: 50
[12]	Minakuchi H, Nakanishi K, Soga N, Ishizuka N, Tanaka N. Anal Chem, 1996, 68: 3 498
[13]	Tanaka N, Kobayashi H, Ishizuka N, Minakuchi H, Nakanishi K, Hosoya K, Ikegami T. J Chromatogr A, 2002, 965: 35
[14]	Motokawa M, Kobayashi H, Ishizuka N, Minakuchi H, Nakanishi K, Jinnai H, Hosoya K, Ikegami T, Tanaka N. J Chromatogr A, 2002, 961: 53
[15]	Tanaka N, Nagayama H, Kobayashi H, Ikegami T, Hosoya K, Ishizuka N, Minakuchi H, Nakanishi K, Cabrera K, Lubda D. J High Resolut Chromatogr, 2000, 23: 111
[16]	Cabrera K, Lubda D, Eggenweiler H M, Minakuchi H, Nakanishi K. J High Resolut Chromatogr, 2000, 23: 93
[17]	Lubda D, Cabrera K, Kraas W, Schaefer C, Cunningham D. LC-GC North America, 2001, 19: 1 186
[18]	Cabrera K. J Sep Sci, 2004, 27: 843
[19]	Tanaka N, Kimura H, Tokuda D, Hosoya K, Ikegami T, Ishizuka N, Minakuchi H, Nakanishi K, Shintani Y, Furuno M, Cabrera K. Anal Chem, 2004, 76: 1 273
[20]	Kimura H, Tanigawa T, Morisaka H, Ikegami T, Hosoya K, Ishizuka N, Minakuchi H, Nakanishi K, Ueda M, Cabrera K, Tanaka N. J Sep Sci, 2004, 27: 897
[21]	Luo Q, Shen Y, Hixson K K, Zhao R, Yang F, Moore R J, Mottaz H M, Smith R D. Anal Chem, 2005, 77: 5 028
[22]	Hjertén S, Liao J L, Zhang R. J Chromatogr A, 1989, 473: 273
[23]	Tisch T L, Frost R, Liao J L, Lam W K, Remy A, Scheinpflug E, Siebert C, Song H, Stapleton A. J Chromatogr A, 1998, 816: 3
[24]	Hjertén S. Ind Eng Chem Res, 1999, 38: 1 205
[25]	Liao J L. Progr Chromatogr Sci, 2000, 40: 467
[26]	Liao J L, Zhang R, Hjertén S. J Chromatogr, 1991, 586: 21
[27]	Choi J J, Kwon S T. J Microb Biotechnol, 2004, 14: 1 022
[28]	Bibak N, Paul R M J, Freymann D M, Yaseen N R. Anal Biochem, 2004, 333: 57
[29]	Chung Y J, Jeong J R, Lee B C, Kim J Y, Park Y I, Ro J Y. J Microb Biotechnol, 2003, 13: 897
[30]	Josic D, Strancar A. Ind Eng Chem Res, 1999, 38: 333
[31]	Belenkii B G, Podkladenko A M, Kurenbin O I, Mal′tsev V G, Nasledov D G, Trushin S A. J Chromatogr A, 1993, 645: 1
[32]	Strancar A, Podgornik A, Barut M, Necina R. Adv Biochem Eng Biotechnol, 2002, 76: 49
[33]	Branovic K, Lattner G, Barut M, Strancar A, Josic D, Buchacher A. J Immunol Methods, 2002, 271: 47
[34]	Josic D, Reusch J, Lostner K, Baum O, Reutter W. J Chromatogr, 1992, 590: 59
[35]	Giovannini R, Freitag R, Tennikova T B. Anal Chem, 1998, 70: 3 348
[36]	Urthaler J, Schlegl R, Podgornik A, Strancar A, Jungbauer A, Necina R. J Chromatogr A, 2005, 1 065: 93
[37]	Forcic D, Branovic-Cakanic K, Ivancic J, Jug R, Barut M, Strancar A. J Chromatogr A, 2005, 1 065: 115
[38]	Branovic K, Forcic D, Ivancic J, Strancar A, Barut M, Kosutic Gulija T, Zgorelec R, Mazuran R. J Chromatogr B, 2004, 801: 331
[39]	Bencina M, Podgornik A, Strancar A. J Sep Sci, 2004, 27: 801
[40]	Peters E C, Svec F, Fréchet J M J. Chem Mater, 1997, 9: 1 898
[41]	Podgornik A, Barut M, Strancar A, Josic D, Koloini T. Anal Chem, 2000, 72: 5 693
[42]	Podgornik A, Jancar J, Merhar M, Kozamernik S, Glover D, Cucek K, Barut M, Strancar A. J Biochem Biophys Meth, 2004, 60: 179
[43]	Svec F, Fréchet J M J. Anal Chem, 1992, 54: 820
[44]	Moore R E, Licklider L, Schumann D, Lee T D. Anal Chem, 1998, 70: 4 879
[45]	Oberacher H, Huber C G. Trends Anal Chem, 2002, 21: 166
[46]	Huang X, Zhang S, Schultz G A, Henion J D. Anal Chem, 2002, 74: 2 336
[47]	Holdsvendova P, Coufal P, Suchankova J, Tesarova E, Bosakova Z. J Sep Sci, 2003, 26: 1 623
[48]	Moravcova D, Jandera P, Urban J, Planeta J. J Sep Sci, 2003, 26: 1 005
[49]	Ivanov A R, Zang L, Karger B L. Anal Chem, 2003, 75: 5 306
[50]	Chen H S, Rejtar T, Andreev V, Moskovets E, Karger B L. Anal Chem, 2005, 77: 2 323
[51]	Viklund C, Ponten E, Glad B, Irgum K, Horsted P, Svec F. Chem Mater, 1997, 9: 463
[52]	Yu C, Svec F, Fréchet J M J. Electrophoresis, 2000, 21: 120
[53]	Lee D, Svec F, Fréchet J M J. J Chromatogr A, 2004, 1 051: 53
[54]	Lubbad S, Mayr B, Huber C G, Buchmeiser M R. J Chromatogr A, 2002, 959: 121
[55]	Mayr B, Hoelzl G, Eder K, Buchmeiser M R, Huber C G. Anal Chem, 2002, 74: 6 080
[56]	Gatschelhofer C, Magnes C, Pieber T R, Buchmeiser M R, Sinner F. J Chromatogr A, 2005, 1 090: 81
[57]	Xie S, Allington R W, Svec F, Fréchet J M J. J Chromatogr A, 1999, 865: 169
[58]	Hoelzl G, Oberacher H, Pitsch S, Stutz A, Huber C G. Anal Chem, 2005, 77: 673
[59]	Walcher W, Oberacher H, Troiani S, Holzl G, Oefner P J, Zolla L, Huber C G. J Chromatogr B, 2002, 782: 111
[60]	Premstaller A, Oberacher H, Huber C G. Anal Chem, 2000, 72: 4 386
[61]	Xie S, Allington R W, Fréchet J M J, Svec F. Adv Biochem Eng Biotechnol, 2002, 76: 88
[62]	Rohr T, Hilder E F, Donovan J J, Svec F, Fréchet J M J. Macromolecules, 2003, 36: 1 677
[63]	Iberer G, Hahn R, Jungbauer A. LC-GC, 1999, 17: 998
[64]	Al Bokari M, Cherrak D, Guiochon G. J Chromatogr A, 2002, 975: 275
[65]	Miller S. Anal Chem, 2004, 76: 99A

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