体液的在线样品前处理技术及其小分子化合物的液相色谱-质谱分析

色谱 , 2007, 25(5): 646-653. doi: 10.3321/j.issn:1000-8713.2007.05.008

体液的在线样品前处理技术及其小分子化合物的液相色谱-质谱分析

刘敏 ^1, , 赵利霞 ^2, , 郭宝元 ^3, , 林金明 ^4,

1.中国科学院生态环境研究中心,环境化学与生态毒理国家重点实验室,北京,100085

2.中国科学院生态环境研究中心,环境化学与生态毒理国家重点实验室,北京,100085

3.中国科学院生态环境研究中心,环境化学与生态毒理国家重点实验室,北京,100085

4.中国科学院生态环境研究中心,环境化学与生态毒理国家重点实验室,北京,100085

基金项目: 中国科学院方向性项目(KZCX3-SW-432)

关键词：在线固相萃取 , 液相色谱-质谱 , 小分子化合物 , 体液 , 综述

Development of On-Line Sample Preparation Coupled with Liquid Chromatography-Mass Spectrometry for Analysis of Small Molecules in Biofluids

在线样品前处理液相色谱-质谱联用技术为体液中痕量小分子化合物提供了高灵敏度、高选择性和高通量的分析方法.该文以在线固相萃取柱为主线,总结了不同种类富集柱的特点及其近5年来在相关领域的应用,并简要介绍了在线液相色谱-质谱分析的流路系统.

参考文献

[1]	Barrett Y C,Akinsanya B,Chang S Y,Vesterqvist O.J Chromatogr B,2005,821:159
[2]	Bourgogne E,Grivet C,Hopfgartner G.J Chromatogr B,2005,820;103
[3]	Preuss R,Koch H M,Angerer J.J Chromatogr B,2005,816:269
[4]	Vintiloiu A,Mullett W M,Papp R,Lubd D,Kwong E.J Chromatogr A,2005,1 082:150
[5]	Friedrich G,Appel K,Rose T,Wangemann M,Althaus M,Rissler K.J Chromatogr B,2004,808:131
[6]	Koch H M,Gonzalez-Reche L M,Angerer J.J Chromatogr B,2003,784:169
[7]	Kawano S I,Takahashi M,Hine T,Yamamoto E,Asakawa N.Rapid Commun Mass Spectrom,2005,19:2 827
[8]	Suenami K,Lim L W,Takeuchi T,Sasajima Y,Sato K,Takekoshi Y,Kanno S.J Sep Sci,2006,29:2 725
[9]	Yang S M,Liu L L,Gerson S L,Xu Y.J Chromatogr B,2003,795:295
[10]	Ceglareka U,Lembckea J,Fiedlera G M,Wernera M,Witzigmannb H,Haussb J P,Thiery J.Clin Chim Acta,2004,346:181
[11]	Christiaens B,Fillet M,Chiap P,Rbeida O,Ceccato A,Streel B,Graevec J D,Crommen J,Hubert P.J Chromatogr A,2004,1 056:105
[12]	Ye X Y,Kuklenyik Z,Needham L L,Calafat A M.Anal Chem,2005,77:5 407
[13]	Ye X Y,Kuklenyik Z,Bishop A M,Needham L L,Calafat A M.J Chromatogr B,2006,844:53
[14]	Xu X H,Yan K X,Song H C,Lo M W.J Chromatogr B,2005,814:29
[15]	Hua Y S,Fan-Havard P,Chan K K.J Chromatogr B,2004,809:1
[16]	Fuh M R,Lin S W,Chen L L,Lin T Y.Talanta,2007,72:1 329
[17]	Amini N,Crescenzi C.J Chromatogr B,2003,795:245
[18]	Papp R,Mullett W M,Kwong E.J Pharm Biomed Anal,2004,36:457
[19]	Sakaguchi T,Yamamoto E,Kushida I,Kajima T,Asakawa N.J Pharm Biomed Anal,2006,40:345
[20]	Mullett W M,Walles M,Levsen K,Borlak J,Pawliszyn J.J Chromatogr B,2004,801:297
[21]	Ong V S,Cook K L,Kosara C M,Brubaker W F.Int J Mass Spectrom,2004,238:139
[22]	Xia Y Q,Bakhtiar R,Franklin R B.J Chromatogr B,2003,788:317
[23]	Kato K,Shoda S,Takahashi M,Doi N,Yoshimura Y,Nakazawa H.J Chromatogr B,2003,788:407
[24]	Niederlnder H A G,Koster E H M,Hilhorst M J,Metting H J,Eilders M,Oomsb B,Jong G J.J Chromatogr B,2006,834:98
[25]	Li M,Alnouti Y,Leverence R,Bi H,Gusev A I.J Chromatogr B,2005,825:152
[26]	Dai S J,Song H F,Dou G F,Qian X H,Zhang Y J,Cai Y,Liu X W,Tang Z M.Rapid Commun Mass Spectrom,2005,19:1 273
[27]	Quinn H M,Takarewski J J.International Patent,WO97/16724,1997
[28]	Zeng W,Wang A Q,Fisher A L,Musson D G.Rapid Commun Mass Spectrom,2003,17:2 475
[29]	Zang X,Luo R,Song N,Chen T K,Bozigian H.Rapid Commun Mass Spectrom,2005,19:3 259
[30]	Lai F,Khojasteh-Bakht S C.J Chromatogr B,2005,814:225
[31]	Sadagopan N,Pabst B,Cohen L.J Chromatogr B,2005,820:59
[32]	Lavén M,Markides K,Lngstrom B.J Chromatogr B,2004,806:119
[33]	Mao Y,Huang M Q,Xia Y Q,Jemal M.J Pharm Biomed Anal,2007,43:1 808
[34]	Gjerde J,Kisang E R,Hauglid M,Holm P I,Mellgren G,Lien E A.J Chromatogr A,2005,1 082:6
[35]	Zhang J,Musson D G.J Chromatogr B,2006,843:47
[36]	Xu Y,Grem J L.J Chromatogr B,2003,783:273
[37]	Ynddal L,Hansen S H.J Chromatogr A,2003,1 020:59
[38]	Xue Y J,Turner K C,Meeker J B,Pursley J,Arnold M,Unger S.J Chromatogr B,2003,795:215
[39]	Kahlich R,Gleiter C H,Laufer S,Kammerer B.Rapid Commun Mass Spectrom,2006,20:275
[40]	Grozav A G,Hutson T E,Zhou X,Bukowski R M,Ganapathi R,Xu Y.J Pharm Biomed Anal,2004,36:125
[41]	Koal T,Deters M,Casetta B,Kaever V.J Chromatogr B,2004,805:215
[42]	Zeng H,Deng Y Z,Wu J T.J Chromatogr B,2003,788:331
[43]	Desilets C P,Rounds M A,Regnier F E.J Chromatogr,1991,544:25
[44]	Rudolphi A,Vielhauer S,Boos K S,Seidel D,Bathge I M,Berger H.J Pharm Biomed Anal,1995,13:615
[45]	Kawano S I,Murakita H,Yamamoto E,Asakawa N.J Chromatogr B,2003,792:49
[46]	Kanda T,Kutsuna H,Ohtsu Y,Yamaguchi M.J Chromatogr A,1994,672:51
[47]	Hsieh Y S,Bryant M S,Brisson J M,Ng K,Korfmacher W A.J Chromatogr B,2002,767:353
[48]	Hsieh Y S,Brisson J M,Ng K,Korfmacher W A.J Pharm Biomed Anal,2002,27:285
[49]	Asakawa Y,Ozawa C,Osada K,Kaneko S,Asakawa N.J Pharm Biomed Anal,2007,43:683
[50]	Egle H,Trittler R,Konig A,Kümmerer K.J Chromatogr B,2005,814:361
[51]	Liu M,Hashi Y,Pan F Y,Yao J G,Song G Q,Lin J M.J Chromatogr A,2006,1 133:142
[52]	Baeyens W R G,Weken G,Haustraete J,Aboul-Enein H Y,Corveleyn S,Remon J P,Garcia-Campana A M,Deprez P.J Chromatogr A,2000,871:153
[53]	Ng K Y,Zhou H Y,Zhang Y L,Hybertson B,Randolph T,Christians U.J Chromatogr B,2007,847,188
[54]	Okamoto M,Yamashita K,Nakai K.J Pharm Biomed Anal,2006,41:707
[55]	Chao M R,Wang C J,Yang H H,Chang L W,Hu C W.Rapid Commun Mass Spectrom,2005,19:2 427
[56]	Heinig K,Bucheli F.J Pharm Biomed Anal,2004,34:1 005
[57]	Calderoli S,Colombo E,Frigerio E,James C A,Sibum M.J Pharm Biomed Anal,2003,32:601
[58]	Estrela R C E,Salvadori M C,Suarez-Kurtz G.Rapid Commun Mass Spectrom,2004,18:1 147
[59]	Raices R S L,Salvadori M C,Estrela R C E,Aquino Neto F R,Suarez-Kurtz G.Rapid Commun Mass Spectrom,2003,17:1 611
[60]	Yang Y J,Lee J,Choi M H,Chung B C.Biomed Chromtogr,2003,17:219
[61]	Xu R N,Fan L M,Kim G E,El-Shourbagy T A.J Pharm Biomed Anal,2006,40:728
[62]	Kato K,Silva M J,Needham L L,Calafat A M.Anal Chem,2005,77:2 985
[63]	Lua A C,Sutono Y,Chou T Y.Anal Chim Acta,2006,576:50

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体液的在线样品前处理技术及其小分子化合物的液相色谱-质谱分析

Development of On-Line Sample Preparation Coupled with Liquid Chromatography-Mass Spectrometry for Analysis of Small Molecules in Biofluids

参考文献