建立了超高效液相色谱-串联质谱(UPLC-MS/MS)测定化妆品中常见的6种抗生素(美满霉素、土霉素、四环素、金霉素、多西环素、氯霉素)及甲硝唑的方法,并用于实际样品的分析.样品经甲醇-0.1 mol/L甲酸溶液(体积比为1:1)超声提取后,以甲醇(含1%甲酸)-水(含1%甲酸)为流动相,经UPLC梯度洗脱分离后以多反应监测(MRM)模式质谱测定.方法的检出限为3~20 ng/g,回收率为87%~101%,工作曲线的线性相关系数大于0.995,线性范围为2~1 000μg/L(达3个数量级).对11份市售化妆品进行分析检测,其中2份检出氯霉素,质量分数分别为0.37%和0.19%;1份检出甲硝唑,质量分数为1.02%;美满霉素、土霉素、四环素、金霉素、多西环素未检出.
参考文献
[1] | Health Ministry of People' s Republic of China.Hygienic standard for cosmetics (中华人民共和国卫生部.化妆品卫生规范).2007 |
[2] | Wu D N,Zheng H H,gang L H,et al.Chinese Journal of Health Laboratory Technology (吴大南,郑和辉,杨丽华,等.中国卫生检验杂志).2006,16(2):216 |
[3] | Zhong Y,Luo X Y,Guo C S,et al.Journal of Environment and Health (钟嶷,罗晓燕.郭重山,等.环境与健康杂志),2007,24(6):440 |
[4] | Health Ministry of People' s Republic of China.China Cosmetics Review (中华人民共和国卫生部.中国化妆品),2006,9:12 |
[5] | Wu T,Wang C,Li N.Chinese Journal of Analysis Laboratory (武婷,王超,李楠.分析试验室),2007,26(8):52 |
[6] | Wang P,Li J,Zheng H H.Chinese Journal of Chromatography (王萍,李洁,郑和辉.色谱),2007,25(5):743 |
[7] | Yang Y W,Zhu Y,Zhang W Q,et al.Journal of Environment and Health (杨艳伟,朱英,张卫强,等.环境与健康杂志),2006,23(3):264 |
[8] | Zheng H H,Wang P,Lid.Chinese Journal of Chromatography (郑和辉,王萍,李洁.色谱),2007,25(2):238 |
[9] | Bogusz M J,Hassan H,Al-Enazi E,et al.J Chromatogr B,2004,807:343 |
[10] | Daeseleire E,De Ruyck H,Van Renterghem R.Analyst,2000,125:1 533 |
[11] | Andersen W C,Roybal J E,Gonzales S A,et al.Anal Chim Acta,2005,529:145 |
[12] | Fang D S.Strait Pharmaceutical Journal (方东升.海峡药学),2005,17(2):43 |
[13] | Xie W P,Chen C Z,Huang Y Y,et al.Chinese Journal of Chromatography (谢维平,陈春祝,黄盈煜,等.色谱),2006,24 (6):659 |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%