聚己内酯的表面光化学接枝改性以及细胞相容性

材料研究学报, 2002, 16(3): 233-237. doi: 10.3321/j.issn:1005-3093.2002.03.003

聚己内酯的表面光化学接枝改性以及细胞相容性

竺亚斌 ^1, , 高长有 ^2, , 计剑 ^3, , 沈家骢 ^4,

1.浙江大学

2.浙江大学

3.浙江大学

4.浙江大学

基金项目: 国家重点基础研究发展计划(973计划)(G1999054305)

关键词：聚己内酯 , 甲基丙烯酸 , 光化学接枝 , 内皮细胞

PHOTO-INDUCED GRAFTING OF POLY (METHACRYLIC ACID) ONTO POLYCAPROLACTONE TOWARDS PROMOTION OF CELL COMPATIBILITY

采用紫外光氧化接枝的方法将亲水性的聚甲基丙烯酸(PMAA)接枝到聚己内酯(PCL)表面,用水溶性碳化二亚胺-1-二甲基胺丙基-3-乙基碳化二亚胺作为缩合剂在接枝膜表面固定了明胶,并用衰减全反射红外光谱(ATR-FTIR)和光电子能谱(XPS)对其表面进行了表征.测量了水相动态接触角,研究了细胞相容性.结果表明,经过改性后的PCL膜表面的亲水性显著提高,内皮细胞在改性PCL表面上培养96 h后的细胞增殖率和活性均有明显提高.

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聚己内酯的表面光化学接枝改性以及细胞相容性

PHOTO-INDUCED GRAFTING OF POLY (METHACRYLIC ACID) ONTO POLYCAPROLACTONE TOWARDS PROMOTION OF CELL COMPATIBILITY

参考文献