提出了以聚乳酸/钙磷盐/胶原的骨组织工程支架快速成形制造的材料系统,对比了两种在聚乳酸(PLA)表面涂覆钙磷盐的工艺.一种是将聚乳酸组织工程支架浸泡在模拟体液中采用平衡反应法沉积钙磷盐;另一种是在聚乳酸薄膜上采用非平衡反应法沉积钙磷盐;系统地研究了沉积时间和沉积量、钙磷摩尔比和相结构演变的关系;通过控制反应时间和调整反应物配比获得磷酸四钙(TetCP)-PLA和无定形磷酸钙(ACP)-PLA等材料组合;并对所获得的复合材料进行生物相容性试验.对比试验证明细胞在材料表面生长良好,采用两种方法涂覆钙磷盐均改进了聚乳酸的生物相容性.
参考文献
| [1] | Z.Xiong, Y.Yan, R.Zhang, L.Sun, Fabrication of porous poly (L-lactic acid) scaffolds for bone tissue engineering via precise extrusion, 45, 773(2001) |
| [2] | YAN Yongnian(颜永年),CUI Fuzhai(崔福斋),ZHANG Renji(张人佶),HU Yunyu(胡蕴玉),Rapid Prototyping Manufacturing for Artificial Human Bone(人工骨的快速成形制造),Materials Review(材料导报),14,11(2000) |
| [3] | WANGLi(王笠),YAN Yongnian(颜永年),XIONG Zhuo(熊卓),ZHANG Renji(张人佶),Analysis and Realization of Rapid Prototyping for Materials of Bone Tissue Engineering,(骨组织工程材料快速成形的分析和实验)Materials Review(材料导报),15,49(2001) |
| [4] | YU Yaotin(俞耀庭),ZHANG Xindong(张兴栋),Bio-medical Materials(生物医用材料)(Tianjin,Tianjin University Press,2000)p.134～145 |
| [5] | XIONG Zhuo(熊卓),YAN Yongnian(颜永年),CHEN Lifeng(陈立峰),ZHANG Renji(张人佶),Two New Rapid Prototyping Technologies for Cell Delivery Scaffolds of Bone Tissue Engineering(骨组织工程细胞载体的两种快速成形新工艺),China Mechanical Engineering(中国机械工程),12,515(2001) |
| [6] | WANG Li(王笠),Research on Materials for Rapid Prototyping Manufacturing of Bone Tissue Engineering Scaffolds(骨组织工程支架快速成形制造的材料研究),Master Thesis of Tsinghua University(清华大学硕士学位论文)(2002) |
| [7] | LI Shipu(李世普),Introduction of Bio-medical Materials(生物医用材料导论)(Wuhan,Wuhan Polytechnology University Press, 2000) p.228～241 |
| [8] | L.Lu, A.G.Mikos, Porous poly(L-lactic acid)/apatite composites created by biomimetic process, MRS Bulletin, 21, 28(1996) |
| [9] | R.Y.Zhang, P.X.Ma, The importance of new processing techniques in tissue engineering, J.Biomedical Material Research, 45, 285(1999) |
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