在超临界CO2(SC-CO2)条件下制备了生物相容性良好的聚乳酸(PLA)多孔材料,研究了PLA的分子量、SC-CO2的压力、温度和处理时间对多孔材料的结构形态、孔隙率和玻璃化温度的影响.结果表明:支架材料的孔洞分布、结构形态和孔隙率不仅与聚乳酸的分子量有关,而且与处理样品的压力、温度和时间关系密切;经超临界CO2处理后材料的玻璃化温度(Tg)有所升高.与传统的方法所制得的材料相比较,多孔材料不仅杂质少,孔径孔率分布均匀,孔洞表面粗糙,而且在大孔之间几乎布满了直径为10～20 μm的微孔.该结构提供了营养物质和新陈代谢的通道,且细胞和生长因子也能通过.
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