采用明胶和氯化钠颗粒作为致孔剂,使用溶剂浇铸/颗粒沥滤法制备了高孔隙率、孔间连通和高机械性能的聚乳酸支架,采用软骨细胞体外培养研究了这两种多孔支架对细胞生长性能的影响.结果表明,软骨细胞在以明胶颗粒为致孔剂制备的多孔支架中的相对数量和GAG的分泌量更多,细胞的活性更高.
参考文献
| [1] | J.S.Temenoff,A.G.Mikos,Biomaterials,21,431(2000) |
| [2] | C.V.Vacanti,R.Langer,B.Schloo,J.P.Vacanti,Plastic and Reconstructive Surgery,88,753(1991) |
| [3] | Y.L.Cao,J.P.Vacanti,K.T.Paige,J.Upton,C.A.Vacanti,Plastic and Reconstructive Surgery,100,297(1997) |
| [4] | Peter X.Ma,Materials Today,7(5),30(2004) |
| [5] | W.S.Kim,J.P.Vacanti,L.Cima,D.Mooney,J.Upton,W.C.Puelacher,C.A.Vacanti,Plastic and Reconstructive Surgery,94,233(1994) |
| [6] | A.G.Mikos,A.J.Thorsen,L.A.Czerwonka,R.Langer,Polymer,35(5),1068(1994) |
| [7] | Ch.Schugens,V.Maquet,Ch.Grandfils,R.Jerome,Ph.Teyssie,J.Biomed.Mater.Res.,30,449(1996) |
| [8] | Y.S.Nam,T.G.Park,J.Biomed.Mater.Res.,47,8(1999) |
| [9] | C.Y.Gao,A.Li,L.X.Feng,X.S.Yi,J.C.Shen,Polymer International,49,323(2000) |
| [10] | C.Y.Gao,A.Li,L.X.Feng,X.S.Yi,J.C.Shen,Journal of Applied Polymer Science,81,3523(2001) |
| [11] | K.Whang,C.H.Thomas,K.E.Healy,Polymer,36,837(1995) |
| [12] | ZHANG Run,DENG Zhengxing,LI Lihua,ZHOU Changren,Chinese Journal of Materials Research,17,665(2003)(张润,邓政兴,李立华,周长忍,材料研究学报,17,665(2003)) |
| [13] | ZHANG Renji,XIONG Zhuo,WANG Li,Chinese Journal of Materials Research,17,145(2003)(张人佶,熊卓,王笠,材料研究学报,17,145(2003)) |
| [14] | A.G.Mikos,G.Sarakinos,S.M.Leite,J.P.Vacanti,R.Langer,Biomaterials,14,323(1993) |
| [15] | Z.W.Ma,C.Y.Gao,Y.H.Gong,J.C.Shen,Journal of Biomedical Materials Research B,67B,610(2003) |
| [16] | A.Schindler,D.Harper,Journal of Applied Polymer Science,17,2593(1979) |
| [17] | D.T.Cheung,N.Perelman,E.C.Ko,M.E.Nimni,Connect Tissue Res.,13,109(1985) |
| [18] | Z.W.Ma,C.Y.Gao,Y.H.Gong,J.C.Shen,Biomaterials,24(21),3725(2003) |
| [19] | S.Bancel,W.S.Hu,Biotechnol.Prog.,12,398(1996) |
| [20] | Q.L.Zhou,Y.H.Gong,C.Y.Gao,Journal of Applied Polymer Science,98(3),1373(2004) |
| [21] | Y.B.Zhu,C.Y.Gao,T.He,J.C.Shen,Biomaterials,25,423(2004) |
| [22] | C.Y.Gao,J.J.Guan,Y.B.Zhu,J.C.Shen,Macromolecular Bioscience,3,157(2003) |
| [23] | GAO Changyou,YUAN Jun,GUAN Jianjun,SHEN Jiacong,Chemical Journal of Chinese Universities,23,1210(2002)(高长有,袁峻,管建均,沈家骢,高等学校化学学报,23,1210(2002)) |
| [24] | Z.W.Ma,C.Y.Gao,Y.H.Gong,J.Ji,J.C.Shen,Journal of Biomedical Materials Research Part B,Applied Biomaterials,63,838(2002) |
| [25] | Z.W.Ma,C.Y.Gao,J.Ji,J.C.Shen,European Polymer Journal,38,2279(2002) |
| [26] | ZHU Yabin,GAO Changyou,LIU Yunxiao,GONG Yihong,SHEN Jiacong,Chemical Journal of Chinese Universities,25,1347(2004)(竺亚斌,高长有,刘云肖,龚逸鸿,沈家骢,高等学校化学学报,25,1347(2004)) |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%