泡沫碳化硅的生物相容性

材料研究学报, 2008, 22(1): 58-62. doi: 10.3321/j.issn:1005-3093.2008.01.010

泡沫碳化硅的生物相容性

吴琳 ^1, , 徐兴祥 ^2, , 李波 ^3, , 王禄增 ^4, , 戚忠政 ^5, , 曹小明 ^6, , 田冲 ^7, , 张劲松 ^8,

1.中国医科大学口腔医学院修复科,沈阳,110002

2.中国科学院金属研究所,沈阳,110016

3.中国医科大学发育生物学研究室,沈阳,110001

4.中国医科大学实验动物部,沈阳,110001

5.中国医科大学口腔医学院修复科,沈阳,110002

6.中国科学院金属研究所,沈阳,110016

7.中国科学院金属研究所,沈阳,110016

8.中国科学院金属研究所,沈阳,110016

关键词：无机非金属材料 , 骨修复材料 , 生物相容性 , 泡沫碳化硅

Biocompatibility of silicon carbide foam

依据国家标准 GB/T16886,评价了用"高分子热解结合可控熔渗反应烧结技术一制备的泡沫碳化硅的生物相容性.结果表明:这种泡沫碳化硅没有细胞毒性,没有潜在的皮肤致敏性,遗传毒性试验、皮下和骨植入试验均未见异常反应,具有良好的生物相容性,可应用在外形复杂和长段承重骨缺损的修复.

参考文献

[1]	L.Cerroni,R.Filocamo,M.Fabbri,C.Piconi,S.Caropreso.S.G.Condò,Growth of osteoblast-like cells on Dorous bydroxyapatite ceramics:an in vitro study,Biomolecular Engineering,19,119(2002)
[2]	BAO Chongyun,ZHANG Xingdong.Research development and prospect of calcium phosphate biomaterials with intrinsic osteoinductivity,J.Biomed.Eng.,23(2),442(2006)(包崇云,张兴栋,磷酸钙生物材料固有骨诱导性的研究现状与展望,生物医学工程学杂志,23(2),442(2006))
[3]	Uldis Kalnins,Andrejs Erglis,Iveta Dinne.Indulis Kumsars,Sanda Jegere,Clinical outcomes of silicon carbide coated stents in patients with coronary artery disease,Med.Sci.Monit.,8(2),16(2002)
[4]	Chong TIAN,Jinsong ZHANG,Xiaoming CAO,High strength silicon carbide foams and their deformation be havior,J.Mater.Sci.Technol.,22(2),269(2006)
[5]	Zhang Jinsong,Cao Xiaoming,Tian Chong,YangZhenming,Compact foamed thyrite with high inteusity and preparation method of the same,World Patent.WO2007056895(2007)
[6]	GB/T16886.1-2001,Biological evaluation of medical devices-Part1:evaluation and testing.(中华人民共和国国家标准GB/T16886.1-2001医疗器械生物学评价第1部分:评价与试验)
[7]	TIAN Jiajun,ZHENG Hua,CHEN Dunchun,WANG Dingguo,Biological evaluation of biological derivation bone tissue engineering scaffold.Beijing Biomedical Engineering,22(4),281(2003)(田嘉军,郑华,陈敦春,王定国,生物衍生组织工程骨支架材料生物学评价,北京生物医学工程,22(4),281(2003))
[8]	W.Sun,J.E.Puzas,T.J.Sheu,X.Liu,P.M.Fauchet.Nanoto microscale porous silicon as a cell interface for bonetissue engineering,Advanced Materials,19,921(2007)
[9]	CAO Xiaoming,Fabrication and properties of SiC foam ceramic and SiC foam/Al co-continuous composites,PhD Dissertation,Institute of Metal Research Chinese Academy of Sciences(2007)(曹小明,碳化硅泡沫陶瓷及双连续碳化硅/铝复合材料的制备与性能研究,博士学位论文,中国科学院金属研究所(2007))
[10]	A.de Carlos,J.P.Borrajo,J.Serra,P.Gonzalez,B.Leon.Behaviour of MG-63 osteoblast-like cells on wood-based biomorphic SiC ceramics coated with bioactive glass,J.Mater.Sci.:Mater.Med.,17,523(2006)
[11]	V.Karageorgiou,D.Kaplan,Porosity of 3D biomaterial scaffolds and osteogenesis,Biomaterials,26,5474(2005)

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泡沫碳化硅的生物相容性

Biocompatibility of silicon carbide foam

参考文献