用低温等离子体接枝聚合丙烯酸获得表面羧基化的PLLA膜并对其表面性能进行表征.结果表明,等离子体处理条件对膜表面羧基接枝密度有较大影响;与空白PLLA膜相比,羧基化后膜的亲水性得到显著提高,表面接触角由75°减少到24°并长时间保持稳定;L929成纤维细胞在羧化膜上的生长状态良好,呈现出细胞的聚集态,其细胞密度大于空白组.材料表面的羧基化能改善其亲水性并使其带上负电荷,从而有效的促进细胞的黏附和生长.
参考文献
[1] | T.Groth,G.Altankov,K.Kolsz,Adhesion of human pe-ripheral blood lymphocytes is dependent on surface wet-tability and protein preadsorption,Biomaterials,15(6),423(1994) |
[2] | M.J.Dalby,S.Childs,M.O.Riehle,H.J.Johnstone,S.Aifrossman,A.S.Curtls,Fibroblast reaction to island topography:changes in cytoskeleton and morphology with time,Biomaterials,24(6),927(2003) |
[3] | HONG Yi,GONG Yihong,GAO Changyou,SHEN Jia-cong,Chitosan-modified polylactide microspheres:poten-tially injectable cell carriers for tissue engineering,Chinese Journal of Materials Research,19(6),589(2005)(洪奕,龚逸鸿,高长有,沈家骢,壳聚塘涂层聚乳酸细胞微载体的制备和性能,材料研究学报,19(6),589(2005)) |
[4] | A.B.Gilman,Low-temperature plasma treatment as an ef-fective method for surface modification of polymeric ma-terials,High Energy Chemistry,37(1),17(2003) |
[5] | J.Yang,J.Z.Bei,S.G.Wang,Improving cell affinity of Poly(D,L-lactide) film modified by anhydrous ammonia plasma treatment,Polymers for Advanced Technologies,13(3-4),220(2002) |
[6] | Y.Q.Wan,X.Qu,J.Lu,C.F.Zhu,L.J.Wan,J.L.Yang,J.Z.Bei,S.G.Wang,Characterization of surface property of poly (lactide-co-glycolide) after oxygen plasma treat-ment,Biomaterials,25(19),4777(2004) |
[7] | Z.Ding,J.N.Chen,S.Y.Gao,J.B.Chang,J.F.Zhang,E.T.Kang,Immobilization of chitosan onto poly-L-lactic acid film surface by plasma graft polymerization to control the morphology of fibroblast and liver cells,Biomaterials,25(6),1059(2004) |
[8] | M.H.Ho,L.T.Hou,C.Y.Tu,H.J.Heieh,J.Y.Lai,W.J.Chen,D.M.Wang,Promotion of cell affinity of porous PLLA scaffolds by immobilization of RGD pep-tides via plasma treatment,Macromolecular Bieseience,6(1),90(2006) |
[9] | J.Yang,J.Z.Bei,S.G.Wang,Enhanced cell affinity of poly (L,D-lactide) by combining plasma treatment with colla-gen anchorage,Biomaterials,23(12),2607(2002) |
[10] | G.Bhuvanesh,P.Christopher,B.Isabelle,J.Hilborn,Plasma-induced graft polymerization of acrylic acid onto poly(ethylene terephthalate) films:characterization and human smooth muscle cell growth on grafted films,Biomaterials,23(3),863(2002) |
[11] | C.Hua,B.Georges,Surface modification of poly(ether snifone) ultrafiltration membranes by low-temperature plasma-induced graft polymerization,Journal of Applied Polymer Science,72,1699(1999) |
[12] | HUANG Jian,WANG Xiaolin,CHEN Xiuzhen,YU Xuehal,Preparation of stimuli-responsive mem-brane by plasma graft polymerization of poly(N-isopropylacrylamide) onto PE membrane,Polymer Materials Science and Engineering,19(4),48(2003)(黄健,王晓琳,陈秀珍,余学海,高分子微滤膜等离子体处理接枝N-异丙基丙烯酰胺,高分子材料科学与工程,19(4),48(2003)) |
[13] | YANG Jian,BEI Jianzhong,WANG Shenguo,A new method for improving the cell affinity of poly (D,L-lactide),Chinese Journal of Biomedical Engineering,10(2),63(2001) |
[14] | WAN Yuqing,CHEN Wenna,YANG Jian,BEI Jianzhong,WANG Shenguo,Biodegradable poly (L-lactide)-poly (ethylene glycol) multiblock copolymer:syn-thesis and evaluation of cell affinity,Biomaterials,24(13),2195(2003) |
[15] | Wavhal Dattatray S.,Fisher Ellen R.,Hydrophilic modifi-cation of polyethersulfone membranes by low temperature plasma-induced graft polymerization,Journal of Mem-brane Science,209(1),255(2002) |
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