以高压静电法制备的壳聚糖微球为模板,与海藻酸钠层层自组装制备多层聚电解质膜,再以乙酸溶出壳聚糖微球制备出微胶囊.调节乙酸的浓度及溶出时间以控制核内壳聚糖的残留量,从而诱导负电性荧光素钠的沉积.微胶囊内部荧光素钠的浓度随着包埋时间的增加而呈线性地提高,当荧光素钠溶液的浓度为2 mg/l时其最终包埋的浓度达到10.2 mg/l.这种聚电解质微囊对于小分子负电荷荧光素钠的释放行为主要受其囊壁和内部模板结构的影响,盐离子浓度对荧光素钠释放行为的影响较小.
参考文献
| [1] | LIANG Zhenpeng,WANG Chaoyang,SUN Qilong,TONG Zhen,Novel mierocapsule fabricated by lbl nano self-assembly,Progress in Chemistry,16(4),485(2004)(梁振鹏,王朝阳,孙启龙,童真,LbL层层纳米自组装法制备新型微胶囊,化学进展,16(4),485(2004)) |
| [2] | F.Carnso,E.Donath,H.Mohwald,Influence of polyelectrolyte multilayer coatings on Forster resonance energy transfer between 6-curboxyfluorescein and rhodamine B-labeled particles in aqueous solution,Journal of Physical Chemistry B,102(11),2011(1998) |
| [3] | G.B.Sukhorukov,E.Donath,H.Lichtenfeld,E.Knippel,M.Knippel,A.Budde,H.Mohwald,Layer-by-layer self assembly of polyelectro|ytes on colloidal particles,Colloids and Surfaces A,137(1-3),253(1998) |
| [4] | E.Donath,G.B.Sukhorukov,F.Caruso,S.A.Davis,H.Mohwald,Novel hollow polymer shells by colloidtemplated assembly of polyelectrolytes,Angewandte Chemie-International Edition,37'(16),2202(1998) |
| [5] | G.Sukhorukov,L.Dahne,J.Hartmann,E.Donath,H.M6hwald,Controlled precipitation of dyes into hollow polyelectrolyte capsules based on colloids and biocolloids,Advanced Materials,12(2),112(2000) |
| [6] | D.I.Gittins,F.Caruso,Multilayered polymer nanocapsules derived from gold nanoparticle templates,Advanced Materials,12(24),1947(2000) |
| [7] | N.G.Balabushevitch,G.B.Sukhorukov,N.A.Moroz,D.V.Volodkin,N.I.Larionova,E.Donath,H.Mohwald,Encapsulation of proteins by layer-by-layer adsorption of polyelectrolytes onto protein aggregates:Factors regulating the protein release,Biotechnology and Bioengineering,76(3),207(2001) |
| [8] | X.P.Qiu,E.Donath,H.Mohwald,Permeability of ibuprofen in various polyelectrolyte multilayers,Macromolecular Materials and Engineering,286(10),591(2001) |
| [9] | X.P.Qiu,S.Leporatti,E.Donath,H.Mohwald,Studies on the drug release properties of polysaccharide multilayers encapsulated ibuprofen microparticles,Langmuir,17(17),5375(2001) |
| [10] | D.B.Shenoy,A.A.Antipov,G.B.Sukhorukov,H.Mohwald,Layer-by-layer engineering of biocompatible,decomposable core-shell structures,Biomacromolecules,4(2),265(2003) |
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