制备了以ZnO为促凝剂的n-HA/CS复合骨水泥, 并对其理化性能和固化机理进行了研究. 结果表明, 当ZnO/复合材料比为1/8, 固化液/(复合材料+ZnO)之比(L/P)为1.2mL/g时, 骨水泥的抗压强度及其对应的固化时间均能够满足临床操作的需要; 骨水泥快速固化的机理是其中的Zn2+和Ca2+与壳聚糖的氨基之间发生了络合反应所致, 并形成了密实网络结构, 其较大的收缩力使其中的水分子迅速排出, 从而实现了骨水泥的快速固化, 并赋予其较高的固化强度.
A n-HA/chitosan composite cement containing ZnO as the coagulant was prepared, and its physic-chemical properties and the setting mechanism were also investigated. The results showed that both the compressive strength and the corresponding setting time of the cement could meet with the demand in clinic. A chelate having the tight network structure was formed due to the reaction of Zn 2+ and Ca 2+ ions with amino group of chitosan, which produced a contractive force. The force extruded H2O molecules out of the cement body and made the cement set fast, and with higher compressive strength.
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