用十二醇修饰45S5生物活性玻璃粉体,并制备了45S5生物活性玻璃均匀分散的聚乳酸复合膜.将复合膜在沸水中处理20min后,研究了水解处理对复合膜性能的影响.处理之后,复合膜的亲水性得到恢复; 细胞增殖结果显示,水解处理后的复合膜更能促进骨髓干细胞的增殖与分化.尽管沸水处理之后,复合膜的力学强度有所下降,但仍高于未修饰粉体与聚乳酸复合膜的拉伸强度,说明沸水处理不影响无机颗粒在聚乳酸基体中的分布.沸水处理能够在较好保持复合膜力学性能的同时,有效而快速地恢复修饰后复合膜的亲水性,从而更利于骨髓干细胞的增殖和分化.
45S5 bioactive glasses (BGs) were surfacemodified with dodecyl alcohol through esterification reaction to get 45S5/PDLLA composite films. The properties of the composite films before and after treatment in boiling water for 20min were investigated. The results show that water contact angles of the composite films decrease sharply after the boling water treatment, indicating the improvement of the hydrophilicity of the composite films. Furthermore, after boiling water treatment, the tensile strength of the composite films decrease slightly, and is still higher than that of 45S5 BGs/PDLLA composite films, which illustrate that the treatment in boiling water does not affect the homogeneous dispersion of BGs particles in PDLLA matrix. Most importantly, cells on the composite films after hydrolysis show the highest proliferation rate and differentiation level.
参考文献
| [1] | |
| [2] | |
| [3] | |
| [4] | |
| [5] | |
| [6] | |
| [7] | |
| [8] | |
| [9] | |
| [10] | |
| [11] | |
| [12] | |
| [13] | |
| [14] | ］Jiang G, Evans M E, Jones I A, et al. Preparation of poly(epsiloncaprolactone)/continuous bioglass fibre composite using monomer transfer coulding for bone implant. Biomaterials, 2005, 26（15）：2281-2288. |
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