研究载不同浓度香丹注射液(简称香丹)磷酸钙骨水泥(CPC)的理化性能和药物释放,为优化CPC中载入香丹浓度提供理论依据.将香丹与CPC主要原料之一磷酸氢钙混合烘干代替磷酸氢钙制得一系列载不同浓度香丹的CPC,香丹浓度范围在0.05~0.5mL/g.采用Gilmore针、万能材料力学试验机、X射线衍射仪、傅立叶红外光谱仪表征载不同浓度香丹CPC的理化性能,用扫描电镜观察微观形貌,测定载不同浓度香丹CPC的药物释放.结果表明CPC凝结时间随香丹浓度的增加而延长,浓度不高于0.2mL/g的CPC样品凝结时间符合临床要求;抗压强度随香丹含量的增加而增加;香丹加入对CPC转化没有明显影响,但导致水化产物晶体形貌从颗粒状松散搭接转化为片状交织,且浓度越高片状晶体越多.在药物释放的最初4h,载入香丹浓度范围为0.1~0.5mL/g的CPC其释药量符合临床需要.因此,载入香丹浓度范围为0.1~0.2mL/g的CPC凝结时间符合临床要求,比空白CPC具有更高的抗压强度,在初阶段药物释放量符合治疗需求.
参考文献
[1] | Ginebra M P,Traykova T,Planell J A.Calcium phosphate cements as bone drug delivery systems:a review.J.Control Release,2006,113(2):102-110. |
[2] | 时述山,胥少汀.实用骨与软骨移植.北京:人民军医出版社,2002:189. |
[3] | 黄兆胜,华碧春,冼建春.骨伤中草药与验方.福州:福建科学技术出版杜,2004:6-182. |
[4] | 刘向前.骨伤科常用中药配伍运用.北京:人民军医出版社,2007:251-318. |
[5] | Lin F H,Dong G C,Chen K S,et al.Immobilization of Chinese herbal medicine onto the surface-modified calcium hydrogenphosphate.Biomaterials,2003,24(3):2413-2422. |
[6] | 任鹏宇,刘娟,刘彦宁,等.丹红注射液-磷酸钙骨水泥释放体系的力学性能、显微结构及体外释放.中国组织工程研究与临床康复,2009,13(3):487-492. |
[7] | 姜红江,黄相杰,谭远超,等.磷酸钙骨水泥复方丹参缓释体的制备及性能评价.中国修复重建外科杂志,2007,21(10):1113-1117. |
[8] | Qu S X,Weng J,Feng B,et al.Preliminary study of calcium phosphate immobilized with Chinese medicine.J.Mater.Set.2005,40 (11):3035-3037. |
[9] | Li M H,Qu S X,Shen R,et al.Study on synthesis of calcium phosphate biomaterials containing SMB.Key Eng.Mat.,2007,330-332 (2):1033-1036. |
[10] | 李茂红,屈树新,姚宁,等.含丹参磷酸钙骨水泥的制备和表征.生物医学工程与临床,2005,9(3):132-135. |
[11] | Liu Y R,Qu S X,Maitz M F,et al.The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells.J.Ethnopharmacol.2007,111(3):573-583. |
[12] | Panzavolta S,Torricelli P,Bracci B,et al.Alendronate and Pamidr-onate calcium phosphate bone cements:setting properties and in vitro response of osteoblast and osteoclast cells.J.Inorg.Biochem.,2009,103(1):101-106. |
[13] | Young A M,Ng P Y J,Gbureck U,et al.Characterization of chlorhexidine-releasing,fast-setting,brushite bone cements.Acta.Biomater.,2008,4(4):1081-1088. |
[14] | Khairoun I,Driessens F C M,Boltong M G,et al.Addition of cohesion promoters to calcium phosphate cements.Biomaterials,1999,20(4):393-398. |
[15] | 黄粤,刘昌胜,邵慧芳,等.妥布霉素对磷酸钙骨水泥性能的影响.中国生物医学工程学报,2002,21(5):417-421. |
[16] | Ginebra M P,Fernández E,Boltong M G,et al.Compliance of an apatitic calcium phosphate short-term cement with the short-time clinicl requirments in bone surgery,orthopaedics and dentistry.Clin.Mater.,1994,17(2):99-104. |
[17] | 郜成莹,叶建东.磷酸钙骨水泥负载庆大霉素的制备与表征.材料导报,2008,22(3):151-154. |
[18] | Dos Santos L A,de Olibeira L C,Rigo E C S.Influence of polymeric additives on the mechanical properties of α-tricalcium phosphate cement.Bone,1999,25(2Suppl):99S-102S. |
[19] | Takechi M,Miyamoto Y,Ishikawa K,et al.Effects of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cement.J.Biomed.Mater.Res.,1998,39(2):308-316. |
[20] | 浙江大学化学系分析化学教研室.分析化学手册第一分册.北京:化学工业出版社,1979:55. |
[21] | Doi Y,Shimizu Y,Moriwaki Y,et al.Development of a new calcium phosphate cement that contains sodium calcium phosphate.Biomaterials,2001,22(8):847-854. |
[22] | Yokoyama Atsuro,Yamamoto Satoru,Kawasaki Takao,et al.Development of calcium phosphate cement using chitosan and citric acid for bone substitute materials.Biomaterials,2002,23(4):1091-1101. |
[23] | 宋志国,周大利,尹光福,等.含盐酸四环素α-TCP骨水泥的理化性能.功能材料,2004,35(1):111-113. |
[24] | 邵慧芳,刘昌胜,黄粤,等(SHAO Hui-Fang,et al).羟基磷灰石晶种的形貌控制及其对磷酸钙骨水泥的原位增强研究.无机材料学报(Journal of Inorganic Materials),2001,16(5):933-939. |
[25] | 王文魁,王继扬,赵珊茸.晶体形貌学.武汉:中国地质大学出版社,2001:120. |
[26] | 刘玉荣.多孔磷酸钙骨水泥及丹参/磷酸钙骨水泥复合物的研究.成都:西南交通大学硕士论文,2006. |
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