采用等离子体电解氧化(PEO)技术,在纯钛基体上制备了具有多孔和纳米结构并含有不同钙磷含量的氧化钛涂层.采用扫描电子显微镜和X射线衍射仪研究了涂层的显微结构和相组成.采用模拟体液浸泡实验评价涂层的生物活性.研究结果表明:涂层主要由锐钛矿和金红石相组成,涂层表面孔径小于10μm,晶粒直径约10～100nm,且涂层表面晶粒、涂层厚度、表面粗糙度和涂层中的钙磷元素含量均随着PEO过程中电流密度的增大而增加.PEO涂层在模拟体液中浸泡14 d即能够诱导类骨磷灰石在其表面沉积,显示出良好的生物活性.涂层中的钙磷含量和结晶形态对其生物活性起关键作用.
参考文献
| [1] | Han Y,Hong S H,Xu K W.Porous nanocrystalline titania films by plasma electrolytic oxidation.Surf.Coat.Technol.,2002,154(2/3):314-318. |
| [2] | Han Y,Chen D H,Sun J F,et al.UV-enhanced bioactivity and cell response of micro-arc oxidized titania coatings.Acta Biormater.,2008,4(5):1518-1529. |
| [3] | Hu H J,Liu X Y,Ding C X.Preparation and cytocompatibility of Si-incorporated nanostructured TiO2 coating.Surf.Coat.Technol.,2010,204(20):3265-3271. |
| [4] | Wu C T,Ramaswamy Y,Zreiqat H.Porous diopside (CaMgSi2O6)scaffold:a promising bioactive material for bone tissue engineering.Acta Biomater.,2010,6(6):2237-2245. |
| [5] | Zreiqat H,Ramaswamy Y,Wu C T.The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering.Biomaterials,2010,31(12):3175-3184. |
| [6] | Balasundaram G,Webster T J.A perspective on nanophase materials for orthopedic implant applications.J.Mater.Chem.,2006,16(38):3737-3745. |
| [7] | Hu H J,Liu X Y,Ding C X.Preparation and in vitro evaluation of nanostructured TiO2/TCP composite coating by plasma electrolytic oxidation.J.Alloys Compd.,2010,498(2):172-178. |
| [8] | Liu X Y,Zhao X B,Li B,et al.UV-irradiation-induced bioactivity on TiO2 coatings with nanostructural surface.Acta Biomater.,2008,4(3):544-552. |
| [9] | Ishizawa H,Ogino M.Characterization of thin hydroxyapatite layers formed on anodic titanium oxide coatings containing Ca and P by hydrothermal treatment.J.Biomed.Mater.Res.,1995,29(9):1071-1079. |
| [10] | Huang P,Wang F,Xu K W,et al.Surface modification of titanium implant by microarc oxidation and hydrothermal synthesis.J.Biomed.Mater.Res.B,2004,70(2):187-190. |
| [11] | Park I S,Lee M H,Bae T S,et al.Effects of anodic oxidation parameters on a modified titanium surface.J.Biomed.Mater.Res.B,2008,84(2):422-429. |
| [12] | Wei D Q,Zhou Y,Jia D C,et al.Characteristic and in vitro bioactivity of a microarc-oxidized TiO2-based coating after chemical treatment.Acta Biomater.,2007,3(5):817-827 |
| [13] | Li Y,Lee I S,Cui F Z,et al.The biocompatibility of nanostmctured calcium phosphate coated on micro-arc oxidized titanium.Biomaterials,2008,29(13):2025-2032. |
| [14] | Das K,Bose S,Bandyopadhyay A.Surface modifications and cell-materials interactions with anodized Ti.Acta Biormater.,2007,3(4):573-585. |
| [15] | Kokubo T,Takadama H.How useful is SBF in predicting in vivo bone bioactivity? Biomaterials,2006,27(15):2907-2915. |
| [16] | Guo H F,An M Z,Xu S,et al.Formation of oxygen bubbles and its influence on current efficiency in micro-arc oxidation process of AZ91D magnesium alloy.Thin Solid Films,2005,485(1/2):53-58. |
| [17] | Zhang R F,Shan D Y,Chen R S,et al.Effects of electric parameters on properties of anodic coatings formed on magnesium alloys.Mater.Chem.Phys.,2008,107(2/3):356-363. |
| [18] | Han Y,Chen D H,Zhang L.Nanocrystallized SrHA/SrHASrTiO3/SrTiO3-TiO2 multilayer coatings formed by micro-arc oxidation for photocatalytic application.Nanotechnology,2008,19(33):335705. |
| [19] | Han Y,Sun J F,Huang X.Formation mechanism of HA-based coatings by micro-arc oxidation.Electrochem.Commun.,2008,10(4):510-513. |
| [20] | Gu Y W,Tay B Y,Lim C S,et al.Biomimetic deposition of apatite coating on surface-modified NiTi alloy.Biomaterials,2005,26(34):6916-6923. |
| [21] | Yan X,Yu C,Zhou X,et al.Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities.Angew.Chem.Int.Ed.,2004,43(44):5980-5984. |
| [22] | Li X,Shi J L,Dong X P,et al.A mesoporous bioactive glass/polycaprolactone composite scaffold and its bioactivity behavior J.Biomed.Mater.Res.,2008,84A(1):84-91. |
| [23] | Zhao Y,Zhang Y,Fang N,et al.Synthesis and cellular biocompatibility of two kinds of HAP with different nanocrystal morphology.J.Biomed.Mater.Res.B,2007,83B(1):121-126. |
| [24] | Liu X Y,Zhao X B,Fu R K Y,et al.Plasma-treated nanostructured TiO2 surface supporting biomimetic growth of apatite.Biomaterials,2005,26(31):6143-6150. |
| [25] | Wang G C,Liu X Y,Gao J H,et al.In vitro bioactivity and phase stability of plasma-sprayed nanosturctured 3Y-TZP coatings.Acta Biomater.,2009,5(6):2270-2278. |
| [26] | LeGeros R Z.Calcium phosphate-based osteoinductive materials.Chem.Rev.,2008,108(11):4742-4753. |
| [27] | Dorozhkin S V,Epple M.Biological and medical signiticance of calcium phosphates.Angew.Chem.Int.Ed.,2002,41(17):3130-3146. |
| [28] | Kokubo T,Kim H-M,Kawashita M.Novel bioactive materials with different mechanical properties.Biomaterals,2003,24(13):2161-2175. |
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