以Al2O3-MgO-P2O5磷酸盐为粘结剂, 采用有机泡沫浸渍工艺制备了多孔陶瓷, 采用扫描电镜(SEM)、X射线衍射(XRD)、排水法和压缩实验等表征了多孔陶瓷的孔隙形貌、相组成、孔隙率和力学性能, 并通过体外细胞实验研究了其细胞相容性. 结果表明, Al2O3-MgO-P2O5磷酸盐的加入不仅可以使浆料能够均匀地涂覆在泡沫体上, 也促进了陶瓷的烧结. 得到的多孔陶瓷具有相互连通、分布均匀的孔隙结构(大孔孔径在100~500μm, 还有约为3μm微孔), 平均孔隙率为85.9%±1.6%, 平均压缩强度为(1.04±0.15)MPa; 多孔陶瓷虽然是一种由HA、β-Ca2P2O7和少量含Mg、Al的物相组成的复合磷酸盐陶瓷, 但在体外实验中没有表现出明显的细胞毒性, 并能促进细胞快速增殖与分化, 表明该多孔陶瓷具有良好的细胞亲和性和相容性.
The porous ceramics were prepared by the foam impregnation technology using Al2O3-MgO-P2O5 as binder. Porous morphology, crystalline phase, porosity, and mechanical property were investigated by using scaning electron microscope (SEM), X-ray diffraction (XRD), Archimedes drainage method, and compression tests. It was found that Al2O3-MgO-P2O5 phosphate promoted the sintering of ceramics, and improved coating of ceramic slurry over the foams uniformly. The obtained ceramics have connective, uniform pore structures with macro-pores of about 100-500μm in diameter and micro-pores of about 3μm in diameter. Their average porosity and compressive strength were 85.9%±1.6% and (1.04±0.15) MPa respectively. Although sintered porous ceramics were polyphosphates composed of HA, β-Ca2P2O7 and a few phases including Al and Mg. They had no cytotoxicity and provoked the proliferation and differentiation of marrow stromal stem cells in vitro. Thus it can be concluded that this kind of porous ceramics has good cellular affinity and cytocompatibility.
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