多种表面活化改性方法已用于致密钛表面活化改性, 本研究尝试用不同浓度的硝酸溶液处理浆料发泡法制备的多孔钛. 酸处理多孔钛内孔壁上出现了微小尺寸的酸蚀坑, 其微结构随酸浓度的变化而略有不同, 处理后表面磷灰石沉积能力随酸浓度变化差异显著, 其中以1:1和1:5两种浓度(体积比)的硝酸处理组最强, 并显著促进MG63细胞增殖, 细胞在样品表面和孔内得到良好粘附和铺展. 本研究结果表明硝酸处理活化多孔钛, 方法简单, 不引入杂质, 渗透性好, 可有效活化多孔钛内外表面, 是一种有效的制备生物活性多孔钛的方法.
Surface modification is expected to further activate the titanium implant and has been widely used in dense titanium surface. In this study, porous titanium fabricated by a slurry foaming method was treated by nitric acid solution with different concentrations. Micrometer-sized acid-etched pits were observed on the inner-pore walls of porous titanium and the morphology varied a little with nitric acid concentration. However, the ability to deposit apatite on the treated porous titanium surface changed obviously with nitric acid concentration. The samples treated by nitric acid solution at a ratio of 1:1 and 1:5 (V(HNO3):V(H2O)) showed the best apatite-forming ability. Compared with that non-treated porous titanium, the samples were treated by nitric acid at the ration of 1:1 and 1:5 (V(HNO3):V(H2O)) showed higher MG63s cells viability, better cells adhesion and spreading with cells both on the surface and inside the pores. The results showed that nitric acid treatment, a simple process with less impurity introduced and good penetration inside porous titanium was an effective method to prepare bioactive porous titanium.
参考文献
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