使用羧甲基壳聚糖(CMCS)和明胶(Gel)作为粘结剂,以沉淀法制得的纳米羟基磷灰石(HA)浆料为原料,采用溶胶-凝胶法制备出了粒径分布均匀,几何形态良好的致密HA球粒.其孔隙率为4.7％±0.6％,单粒抗压强度为(8.9±0.4) MPa(颗粒直径为0.5 mm),高于孔隙率为16.4％±0.5％的多孔球的抗压强度(7.9±0.2) MPa.仿生矿化和细胞培养的结果显示致密HA球粒具有良好的生物学性能.
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