CaSiO3陶瓷作为潜在的生物材料受到广泛研究,它生物活性好,但化学稳定性、生物相容性、烧结以及力学性能不理想.本研究利用固相反应法分别将CaSiO3与TiO2以摩尔比2∶1、3∶1以及5∶1进行混合,在1100℃下煅烧制备了物相为β-CaSiO3与CaTiSiO5的CaSiO3/TiO2复合陶瓷.复合陶瓷的化学稳定性、常压下煅烧的致密度、力学性能比CaSiO3陶瓷都得到了较大提升.随着CaSiO3含量上升,复合陶瓷力学性能及化学稳定性上升,但在模拟体液中诱导磷灰石形成的能力明显下降.研究结果表明,CaSiO3/TiO2复合陶瓷是一种有应用潜力的骨修复材料,且材料性能可通过改变组分实现调控以适应骨修复需要.
参考文献
[1] | Sun J Y,Wei L,Liu X Y,et al.Influences of ionic dissolution products of dicalcium silicate coating on osteoblastic proliferation,differentiation and gene expression.Acta Biomater,2009,5(4):1284-1293. |
[2] | Kokubo T,Kushitani H,Sakka S,et al.Solutions able to reproduce invivo surface-structure changes in bioactive glass-ceramic A-W3.J.Biomed.Mater Res.,1990,24(6):721-734. |
[3] | Xue W C,Liu X Y,Zheng X B,et al.In vivo evaluation of plasma-sprayed wollastonite coating.Biomaterials,2005,26(17):3455-3460. |
[4] | Ni S Y,Chang J,Chou L,et al.Comparison of osteoblast-like cell responses to calcium silicate and tricalcium phosphate ceramics in vitro.J.Biomed.Mater Res.B,2007,80B(1):174-183. |
[5] | Wu C,Chang J.Degradation,bioactivity,and cytocompatibility of diopside,akermanite,and bredigite ceramics.J.Biomed.Mater.Res.B,2007,83B(1):153-160. |
[6] | Wu C T,Ramaswamy Y,Soeparto A,et al.Incorporation of titanium into calcium silicate improved their chemical stability and biological properties.J.Biomed.Mater Res.A,2008,86A(2):402-410. |
[7] | Wu C T,Ramaswamy Y,Kwik D,et al.The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties.Biomaterials,2007,28(21):3171-3181. |
[8] | Ramaswamy Y,Wu C,Van Hummel A,et al.The responses of osteoblasts,osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic.Biomaterials,2008,29(33):4392-4402. |
[9] | Vrouwenvelder W C A,Groot C G,Degroot K.Better histology and biochemistry for osteoblasts cultured on titanium-doped bioactive glass:Bioglass 45S5 compared with iron-,titaniun-,fluorine-and boron-containing bioactive glasses.Biomaterials,1994,15(2):97-106. |
[10] | Harle J,Kim H W,Mordan N,et al.Initial responses of human osteoblasts to Sol-Gel modified titanium with hydroxyapatite and titania composition.Acta Biomater.,2006,2(5):547-556. |
[11] | Fukuda C,Goto K,Imamura M,et al.Bioactive bone cement with a low content of titania particles without postsilanization:effect of filler content on osteoconductivity,mechanical properties,and handling characteristics.J.Biomed.Mater.Res.B,2010,95B(2):407-413. |
[12] | Long L H,Chen L D,Bai S Q,et al.Preparation of dense β-CaSiO3 ceramic with high mechanical strength and HAp formation ability in simulated body fluid.J.Eur Ceram.Soc.,2006,26(9):1701-1706. |
[13] | Yu H X,Ning C Q,Ding D Y.Synthesis and protein adsorption of calcium silicate/apatite composite powders.J.Biomater.Tissue Eng.,2012,2(1):76-82. |
[14] | Kokubo T,Takadama H.How useful is SBF in predicting in vivo bone bioactivity? Biomaterials,2006,27(15):2907-2915. |
[15] | Hayakawa S,Tsuru K,Ohtsuki C,et al.Mechanism of apatite formation on a sodium silicate glass in a simulated body fluid.J.Am.Ceram.Soc.,1999,82(8):2155-2160. |
[16] | Lu X,Leng Y.Theoretical analysis of calcium phosphate precipitation in simulated body fluid.Biomaterials,2005,26(10):1097-1108. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%