采用离心法将介孔生物活性玻璃(MBG)和磷酸钙骨水泥(CPC)高效复合制备出介孔/大孔多级孔复合支架材料,评价了其对抗癌药物阿霉素的装载及释放性能.实验结果表明,采用离心法能在大孔支架CPC内有效负载大量的介孔生物活性玻璃,使其比表面积高达100.1 m2/g,负载量达47.2％,而采用传统浸渍法则不能将MBG粉体材料负载于CPC支架上.载药实验发现离心法制备的介孔/大孔复合支架对阿霉素的装载量达到了46 mg/g,是普通大孔CPC支架的11.5倍,且在体外具有药物缓释的特性.
参考文献
| [1] | Wang T W,Wu H C,Wang W R,et al.The development of magnetic degradable DP-bioglass for hyperthermia cancer therapy.J Biomed Mater Res.A,2007,83A(3):828-837. |
| [2] | Geraci M,Birch J M,Alston R D,et al.Cancer mortality in 13 to 29-year-olds in England and Wales.Br.J.Cancer,2007,97(11):1588-1594. |
| [3] | Wang J,Chen P,Liu C.The occurrence,inducement and therapy development of bone cancer.World Journal of Traditional Chinese Orthopedics,2009,10(2):120-121. |
| [4] | Schulman K L,Kohles J.Economic burden of metastatic bone disease in the US.Cancer,2007,109(11):2334-2342. |
| [5] | Anderson P,Salazar-Abshire M.Improving outcomes in difficult bone cancers using multimodality therapy,including radiation:Physician and nursing perspectives.Curr.Oncol.Rep.,2006,8(6):415-422. |
| [6] | Nagarajan R,Clohisy D R,Neglia J P,et al.Function and qualityof-life of survivors of pelvic and lower extrermity osteosarcoma and Ewing's sarcoma:the childhood cancer survivor study,Br.J.Cancer,2004,91(11):1858-1865. |
| [7] | Meyer J S,Mackenzie W.Malignant bone tumors and limb-salvage surgery in children.Pediatr.Radiol.,2004,34(8):606-613. |
| [8] | Felder-Puig R,Formann A K,Mildner A,et al.Quality of life and psychosocial adjustment of young patients after treatment of bone cancer.Cancer,1998,83(1):69-75. |
| [9] | Serrano M C,Portoles M T,Pagani R,et al.In vitro positive biocompatibility evaluation of glass-glass ceramic thermoseeds forhyperthermic treatment of bone tumors.Tissue Eng.A,2008,14(5):617-627. |
| [10] | Hench L L.Bioceramics:from concept to clinic.J.AM.Ceram.Soc.,1991,74(7):1487-1510. |
| [11] | Hench L L.Bioceramics.J.AM.Ceram.Soc.,1998,81(7):1705-1728. |
| [12] | Arcos D,Greenspan D C,Vallet-Regi M.Influence of the stabilization temperature on textural and structural features and ion release in SiO2-CaO-P2O5 Sol-Gel glasses.Chem.Mater.,2002,14(4):1515-1522. |
| [13] | Jokinen M,Rahiala H,Rosenholm J B,et al.Relation between aggregation and heterogeneity of obtained structure in Sol-Gel derived CaO-P2O5-SiO2.J.Sol-Gel.Sci.Technol.,1998,12(3):159-167. |
| [14] | Lindfors N C,Heikkila J T,Aho A J.Long-term evaluation of blood silicon and ostecalcin in operatively treated patients with benign bone tumors using bioactive glass and autogenous bone.J.Biomed.Mater.Res.B,2008,87B(1):73-76. |
| [15] | Takegami K,Sano T,Wakabayashi H,et al.New ferromagnetic bone cement for local hyperthermia.J.Biomed.Mater.Res.,1998,43(2):210-214. |
| [16] | Yan X X,Yu C Z,Zhou X F,et al.Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities.Angew.Chem.Int.Ed.,2004,43(44):5980-5984. |
| [17] | Xia W,Chang J.Well-ordered mesoporous bioactive glasses (MBG):a promising bioactive drug delivery system.J.Control.Release,2006,110(3):522-530. |
| [18] | Zhao L Z,Yan X X,Zhou X F,et al.Mesoporous bioactive glasses for controlled drug release.Micropor.Mesopor.Mater.,2008,109(1/2/3):210-215. |
| [19] | Lopez-Noriega A,Arcos D,Izquierdo-Barba I,et al.Ordered mesoporous bioactive glasses for bone tissue regeneration.Chem.Mater.,2006,18(13):3137-3144. |
| [20] | Fang L R,Weng W J,Shen G,et al.Research for bone tissue engineering scaffolds and biomaterials.Journal of Biomedical Engineering,2003,20(1):148-152. |
| [21] | Zhu M,Wang H X,Liu J Y,et al.A mesoporous silica nanoparticulate/b-TCP/BG composite drug delivery system for osteoarticular tuberculosis therapy.Biomaterials,2011,32(7):1986-1995. |
| [22] | Nielsen O S,Dombernowsky P,Mouridsen H,et al.High-dose epirubicin is not an alternative to standard-dose doxorubicin in the treatment of advanced soft tissue sarcomas.a study of the EORTC soft tissue and bone sarcoma group.Br.J.Cancer,1998,78(12):1634-1639. |
| [23] | Guo M,Yan Y,Zhang H K,et al.Magnetic and pH-responsive nanocarriers with multilayer core-shell architecture of anticancer drug delivery.J.Mater.Chem.,2008,18(42):5104-5112. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%